急性低氧对中度慢性阻塞性肺疾病患者离体肺细小动脉收缩功能的影响  

Effect of acute hypoxia on contractile function of isolated small pulmonary arteries in patients with moderate chronic obstructive pulmonary disease

作　　者：崔建修[1] 张光燕[1] 陈怡静[1] 马珏[1] 赵国栋[1] 

机构地区：[1]广东省医学科学院广东省人民医院麻醉科,广州市510080

出　　处：《中华麻醉学杂志》2013年第5期592-594,共3页Chinese Journal of Anesthesiology

基　　金：基金项目：广东省自然科学基金（10151008004000010）;广东省科技计划项目（9151008004000027）

摘　　要：目的评价急性低氧对中度慢性阻塞性肺疾病（COPD）患者离体肺细小动脉收缩功能的影响。方法择期拟行肺叶切除术的肺癌患者，性别不限，心脏B超提示未见肺动脉高压，术前肺功能检查正常患者7例，诊断为中度COPD患者6例。术中取距肿瘤组织5cm以外的肺组织，分离肺细小动脉，分为对照组（n=7）和实验组（n=6）。在急性低氧状态下采用微血管张力测定仪测定肺细小动脉的收缩幅度。结果实验组离体肺细小动脉的收缩幅度低于对照组（P〈0．01）。结论急性低氧可进一步降低中度COPD患者离体肺细小动脉的收缩功能。Objective To evaluate the effect of acute hypoxia on the contractile function of isolated small pulmonary arteries in patients with moderate chronic obstructive pulmonary disease （COPD） . Methods Seven pa- tients with lung cancer, of both sexes, scheduled for elective pulmonary lobectomy, with no pulmonary hyperten- sion and with normal pulmonary function after examination, were included in the study. Six cases were diagnosed as having moderate COPD. Lung tissues 5 cm away from the tumor tissues were taken during operation and the small pulmonary arteries were isolated and divided into 2 groups： control group （ n = 7） and COPD group （ n = 6）. The contractile amplitude of small pulmonary arteries was detected using vasomotor tone meter under the state of acute hypoxia. Results Contractile amplitude of small pulmonary arteries in response to hypoxic stimulus was sig- nificantly decreased in COPD group compared with control group （ P 〈 0.01 ）. Conclusion Acute hypoxia can fur- ther reduce the contractile function of isolated small pulmonary arteries in patients with moderate COPD.

关 键 词：缺氧 肺疾病 慢性阻塞性 小动脉 

分 类 号：R563[医药卫生—呼吸系统]