不同基质复方南星止痛贴剂中药物释放性能的研究  

Study on drug release performance of compound Nanxing pain pastes with different stromata

作　　者：黎迎[1] 杜守颖[1] 马勇[2] 陆洋[1] 尚可心[1] 

机构地区：[1]北京中医药大学,北京100102 [2]中国医疗保险研究会,北京100716

出　　处：《中国中药杂志》2013年第16期2594-2596,共3页China Journal of Chinese Materia Medica

基　　金：中药制药过程新技术国家重点实验室开放基金项目(SKL2010M0302);北京中医药大学复方中药制药研究创新团队项目(2011-CXTD-13)

摘　　要：该文分别制备复方南星止痛膏的溶剂型压敏胶贴剂和乳液型压敏胶贴剂,采用Franz扩散池法,以微孔滤膜代替皮肤,组成体外释放度测定装置,研究2种基质复方南星止痛贴剂中丁香酚的体外释放。试验结果表明,丁香酚在不同基质贴剂中的24 h累积释放率次序为乳液型压敏胶贴剂>溶剂型压敏胶贴剂,乳液型贴剂和溶剂型贴剂释放过程均符合Higuchi模型和非Fick扩散机制,乳液型压敏胶基质更有利于复方南星止痛膏中丁香酚体外释放。Solvent and emulsion pressure-sensitive patches for compound Nanxing pain paste were prepared respectively in this study, Franz diffusion cell method was adopted to determine in vitro release of eugenol in compound Nanxing pain paste of the two stro- mata, with microfiltration membranes in place of skins. The results of the experiment demonstrated that solvent pressure-sensitive pat- ches were superior to emulsion pressure-sensitive patches in terms of the accumulated release percentage of eugenol, with both of their release processes in line with Higuchi model and non-Fick diffusion mechanism. In conclusion, emulsion pressure-sensitive stroma was more beneficial to in vitro release of eugenol in compound Nanxing pain paste.

关 键 词：复方南星止痛膏 溶剂型压敏胶贴剂 乳液型压敏胶贴剂 释放 

分 类 号：TQ461[化学工程—制药化工]