肺腺癌EGFR基因突变与血清肿瘤标记物的相关性  

Correlation of EGFR mutations with serum level of tumor markers in lung adenocarcinoma

作　　者：潘金兵[1] 侯宇虹[2] 张国俊[3] 

机构地区：[1]河南省人民医院呼吸科,郑州450003 [2]郑州大学第一附属医院急诊科 [3]郑州大学第一附属医院呼吸科

出　　处：《中国实用医刊》2013年第17期9-12,共4页Chinese Journal of Practical Medicine

摘　　要：目的观察肺腺癌表皮生长因子受体（EGFR）基因突变和血清多种肿瘤标记物的相关性。方法通过PCR扩增及DNA测序分析70例肺腺癌EGFR19、21外显子基因突变，同期蛋白芯片．化学发光法检测血清中肿瘤标记物[癌胚抗原（CEA）、糖类抗原（CAl25）、CAl99、C242和CAl53]水平，统计分析所得结果。结果EGFR基因突变组的血清CEA、CAl99和CA242水平较野生型组高；血清CEA和CA242水平高者EGFR基因突变率高，CEA、CA242及两者联合检测的曲线下面积（AUC）分别为0．724、0．769和0．738，预测EGFR基因突变的敏感性分别为70．4％、37．0％和77．8％。结论血清CEA和CA242水平可作为预测EGFR基因突变指标。Objective To analyze the correlation between the epidemeral growth factor receptor （EGFR） gene mutations and the level of tumor markers in lung adenocarcinoma. Methods EGFR gene was amplified by PCR and sequenced to detect EGFR mutation in 70 lung adenocarcinoma patients, and tumor marks were detected with protein chip-chemiluminescence way, statistical analysis was carried out. Results The serum levels of CA199, CEA and CA242 in EGFR mutation group were higher than those in the wild, high serological CEA and CA242 level had higher rate in the EGFR gene mutation. The are- as of CEA, CA242 and the both under the curve were 0. 724,0. 769 and 0. 738, respectively ; the sensi- tivity to predict EGFR gene mutation were 70. 4%, 37% and 77. 8%, respectively. Conclusions The level of serological CEA and CA242 can be used as indicators to forecast EGFR gene mutations.

关 键 词：肺腺癌 表皮生长因子受体 肿瘤标记物 

分 类 号：R734.2[医药卫生—肿瘤]