组合式配液装置的研制及其在减少不溶性微粒研究的应用  

Experimental study on development of combined type liquid distributing device in reducing the pollution of insoluble particles

作　　者：王晓红[1] 和中月[1] 李红娜[1] 薛丽景[1] 石翠霞[1] 付淑平[1] 

机构地区：[1]河北大学附属医院静脉药物配置中心,河北保定071000

出　　处：《现代预防医学》2013年第17期3277-3279,3283,共4页Modern Preventive Medicine

摘　　要：目的探讨静脉药物配置的最佳方法,减少不溶性微粒进入体内。方法以≥10μm和≥25μm不溶性微粒数为指标,采用光阻法对注射用氨苄西林钠在不同配液器具下的复配液进行微粒测定。结果治疗室环境下,加入相同数量的药物后两组比较差异有统计学意义(P﹤0.001)。静脉药物配置中心(PIVAS)环境下,≥10μm的微粒两组比较差异有统计学意义(P﹤0.001);≥25μm的微粒,加入1支和3支药物后两组比较差异无统计学意义(P﹥0.05),加入6支药物后两组比较差异有统计学意义(P﹤0.001)。结论组合式配液装置能明显的减少不溶性微粒的产生,且随着加药数目的增多在减少较大微粒的优越性愈发明显。OBJECTIVE To discuss the best way of dosing intravenous drugs, to reduce the insoluble particles into the body. METHODS As an indicator of the number of insoluble particles in the ≥ 10μm and ≥ 25μm, used light blockage method to detect particulates in the compound solution of ampieillin sodium in different liquid distribution apparatus. RESULTS In treatment room environment, there were significant differences between the two groups after adding the same number of drugs （P 〈 0.001 ）. In PIVAS environment, two groups had significant differences in ≥ 10μm particles （P 〈 0.001 ） ; , there were significant differences in ≥ 25μm particles between the two groups after adding one and three drugs （P〉 0.05）, it had sig- nificant differences after adding six drugs in two groups （P 〈 0.001 ）. CONCLUSION Combined type liquid distributing device can significantly reduce the generation of insoluble particles, and it has significant superiority in reducing large particles with the increase in the number of dosing.

关 键 词：不溶性微粒 复配液 配液器具 

分 类 号：R197.39[医药卫生—卫生事业管理]