过度运动与肾脏损伤的机制探讨  

Discussion of the mechanism between overexercise and renal trauma

作　　者：王岩[1] 吴任宏[1] 陶洪涛[1] 

机构地区：[1]黄河科技学院附属医院检验科,河南郑州450063

出　　处：《现代预防医学》2013年第17期3303-3306,共4页Modern Preventive Medicine

摘　　要：在过度运动的状态下,肾脏自由基代谢增强,肾小球基底膜和足细胞足突间裂孔隔膜(slit diaphragm,SD)的结构发生改变,通透性增加。裂孔隔膜的完整性是决定肾小球滤过屏障通透性的关键,已发现有多个足细胞相关分子参与了运动性蛋白尿的生成。本文意在阐述过度运动对肾脏损伤的影响,并探讨可能的分子机制与足细胞相关分子(Podocyte associated molecules)的关系。In the situation of overexercise, there is a significant increase of the free radical activity in renal tissues, the structure and permeability of glomerular basement membrane and slit diaphragm （SD） change. The integrity of slit diaphragm is a key factor to the permeability of glomerular filtration barrier and has been found more than one podocytes associated molecules involved in the generation of exercise-induced proteinuria. This article is intended to elaborate the impact of renal trauma induced by overexercise and to explore the relationship between possible molecular mechanism and podocytes associ- ated molecules.

关 键 词：过度运动 足细胞足突间裂孔隔膜 肾脏损伤 分子机制 

分 类 号：R648[医药卫生—外科学]