52例蒙古族肾病综合征患者脂蛋白(a)水平的临床分析  

The clinical analysis of lipoprotein (a) level in 52 Mongolian patients with NS

作　　者：费志宏[1] 周静[1] 孙文阁[1] 莫殿军[2] 朱振远[3] 费志伟[3] 

机构地区：[1]赤峰学院医学院,内蒙古赤峰024000 [2]赤峰学院第一附属医院检验科 [3]赤峰市医院

出　　处：《现代预防医学》2013年第17期3322-3324,共3页Modern Preventive Medicine

基　　金：内蒙古自治区自然科学基金项目(2010MS1115)

摘　　要：目的研究蒙古族肾病综合征nephrotic syndrome(NS)患者脂蛋白(a)(Lp(a))的变化是否与其他血脂测定指标存在相关性。方法采用免疫透射比浊法测定血浆Lp(a)浓度,酶学终点分析法测定血浆甘油三酯(TG)、胆固醇(TC)浓度,磷钨酸-镁沉淀测定高密度脂蛋白-胆固醇(HDL-C)以了解血浆高密度脂蛋白水平,聚乙烯硫酸盐沉淀法测定血浆低密度脂蛋白-胆固醇(LDL-C)以了解血浆低密度脂蛋白水平。结果 NS患者与蒙古族正常对照组相比,NS组血浆LDL-C、TG、TC、Lp(a)浓度均极显著性升高(P﹤0.01),HDL-C浓度有极显著性降低(P﹤0.01)。比较各检测结果发现,蒙古族NS患者血浆Lp(a)浓度的异常率最高,且其浓度的变化与TG、LDL-C浓度变化呈同向性。在疾病治疗的恢复期,血浆Lp(a)浓度呈显著性降低趋势。在蒙古族与汉族正常对照组中差异均无统计学意义。结论对蒙古族NS患者所检测的脂类代谢指标中,Lp(a)是变化最灵敏的指标,具有重要的临床应用价值。OBJECTIVE To investigate correlation between the concentration of Lp （a） and the other lipids in Mongolian patients with NS. METHODS Lp （a） was detected with immuno-turbidimetry, and TG, TC were detected with enzyme method. Measured HDL-C, LDL-C with PTA-Mg2~ and PVS and detected the cholesterol. RESULTS The concentrations of LDL-C, TG, TC, Lp （a） were significantly elevated in comparison with that in normal subjects （P〈 0.01） and HDL-C obviously decreased （P 〈 0.01 ）, among them, the abnormality rate of Lp （a） was the highest, and the variation of its con- centration had positive correlation with TG, LDL-C.On the period of remission, the concentration of plasma Lp （a） showed an obvious decreasing tendency. In controlled groups, there was no statistical difference between Mongolian and Han popula- tion. CONCLUSION Lp （a） is the most sensitive among HDL-C, LDL-C, TG, TC, and should be used in clinic.

关 键 词：蒙古族 肾病综合征患者 脂蛋白(a) 

分 类 号：R692[医药卫生—泌尿科学]