血液灌流治疗尿毒症顽固性高血压疗效观察  

Observation on the effect of hemoperfusion on intractable hypertension of uremia patients

作　　者：郭瑞敏[1] 刘建军[1] 于明忠[1] 张美岩[1] 张岩[1] 陈艳春[1] 

机构地区：[1]河北联合大学附属医院,河北唐山063000

出　　处：《现代预防医学》2013年第17期3327-3328,3331,共3页Modern Preventive Medicine

基　　金：2012年河北省唐山市科技局科技攻关指令课题(12140209A-32)

摘　　要：目的探讨尿毒症顽固性高血压的有效血液净化方式。方法将40例尿毒症顽固性高血压患者随机分两组A组和B组,每组20例。A组患者每周2次常规血液透析加每周1次血液透析滤过;B组患者每周2次常规血液透析加每周1次血液透析滤过加两周1次血液灌流治疗,治疗前后分别观察两组患者血压、血浆内皮素(ET)、血管紧张素Ⅱ(ATⅡ)、肾素(RA)水平、甲状旁腺素(PTH)浓度的变化。结果两组治疗后血压、ET、ATⅡ、RA、PTH均明显降低,与治疗前相比差异有统计学意义,组间比较差异也有统计学意义。结论血液透析(HD)+血液透析滤过(HDF)+血液灌流(HP)OBJECTIVE To investigate the effective modes of blood purification for uremia patients with refractory hyperten- sion. METHODS 40 cases of uremic patients with refractory hypertension were randomly divided into two groups of group A and group B, 20 cases in each group. Group A was given with 2 times conventional hemodialysis and once hemodiafiltration weekly; group B was given patients 2 times routine hemodialysis and once hemodiafiltration weekly and once hemoperfusion in two weeks for treatment. Before and after treatment, changes of blood pressure, plasma endothelin （ET）, angiotensin II （AT II）, renin （RA） level, parathyroid hormone （PTH） concentrations were observed in two groups. RESULTS After treatment, blood pressure, ET, AT II, RA, PTH were decreased, compared with before treatment in two groups, and there was a significant difference, the difference between two groups also had statistical significance. CONCLUSION Hemodialysis （HD） ＋ hemodiafittration （HDF） ＋ hemoperfusion （HP） in the treatment of refractory hypertension treatment is an effective treatment method.

关 键 词：血液透析 血液透析滤过 血液灌流 顽固性高血压 

分 类 号：R544.14[医药卫生—心血管疾病]