吲哚-2,3-二酮抗菌作用研究  

The research of isatin's antibacterial activity

作　　者：殷津津[1] 宋丽阳[1] 杨杰[1] 岳旺[1] 张继国[2] 

机构地区：[1]青岛大学医学院药学系,山东青岛266021 [2]泰山医学院药理学教研室,山东泰安271016

出　　处：《泰山医学院学报》2013年第2期107-109,共3页Journal of Taishan Medical College

摘　　要：目的研究吲哚-2,3-二酮的抗菌作用。方法进行吲哚-2,3-二酮的体内外抗菌实验及急性、慢性毒性实验。结果体外抗菌试验结果显示,吲哚-2,3-二酮最低抑菌浓度(MIC)在大肠杆菌及金黄色葡萄球菌均为750μg/ml,其最低杀菌浓度(MBC)在大肠杆菌及金黄色葡萄球菌均为3000μg/ml。体内抗菌试验结果显示,25 mg/kg吲哚-2,3-二酮可使大肠杆菌和金黄色葡萄球菌导致的小鼠死亡率降低40%。结论吲哚-2,3-二酮有抗菌作用。Objective： To study the isatin＇s antibacterial activity.Methods： Isatin in vivo antibacterial experiments and acute and chronic toxicity experiments were done.Results： The in vitro antimicrobial tests showed that isatin＇s minimum inhibitory concentration（MIC） in Escherichia coli and Staphylococcus aureus was 750μg/ml,the minimum bactericidal concentration（MBC） in E.coli and Staphylococcus aureus was 3000μg/ml.Vivo antibacterial test results showed that 25mg/kg isatin could lead to 40% reduction in mortality caused by E.coli and Staphylococcus aureus in mice.Conclusion： Isatin has an antibacterial effect.

关 键 词：吲哚-2 3-二酮 抗菌 大肠杆菌 葡萄球菌 

分 类 号：R964[医药卫生—药理学]