脓毒症中树突状细胞作用及其变化的研究进展  

The research progress of the function and the change of dendritic cells in sepsis

作　　者：邹云[1] 李金宝[1] 

机构地区：[1]上海第二军医大学附属长海医院麻醉科,200433

出　　处：《国际麻醉学与复苏杂志》2013年第6期568-570,574,共4页International Journal of Anesthesiology and Resuscitation

摘　　要：背景 脓毒症是指感染和创伤等原因引起的微生物进入人体诱发剧烈的全身炎症反应,并引起组织器官继发性损伤,是重症监护室（ICU）主要死亡原因之一. 目的 阐述树突状细胞（dendritic cells,DCs）在脓毒症过程中的变化,从而体现出DCs在脓毒症中起到的关键作用. 内容 DCs功能障碍是脓毒症免疫抑制的主要原因之一,脓毒症中DCs数量减少,并且以未成熟DCs为主,导致其吞噬抗原的能力减弱；脓毒症小鼠中大多脾脏DCs以成熟形态存但是其分泌细胞因子白细胞介素（interleukin,IL）10和IL-12失衡；脓毒症中DCs刺激T细胞增殖的能力减弱.以上所有变化导致机体不能对外来病原体发生免疫应答,导致机体处于免疫抑制状态. 趋势 增加脓毒症中树突状细胞的数目,改善脓毒症中树突状细胞递呈抗原,分泌细胞因子的能力可能成为治疗脓毒症的潜在靶点之一.Background sepsis,induced by pathogenes which were brought through infection or trauma,lead to systemic inflammatory response syndrome and cause secondary injuries of bodies.It is one of the leading reasons of death in Intensive Care Unit.Objective To elaborate the changes of dendritic cells （DCs） and eventually manifest the critical role of DCs in sepsis.Contents Dysfunction of DCs is one of main reason in sepsis which induces immunosuppression.The number of DCs,especially immature DCs,decreased significantly,leading to the weakening of its antigen devouring ability.Much of dendritic cells,which were from the spleen of septic mice,stayed as mature phenotype,with the imbalance between the secretion of cytokines （IL-lO,and IL-12）.Compared with normal mice,the dendritic cells isolated from septic mice,could not stimulate T cells proliferation efficiently.The characteristic mentioned above caused the body to have no responses to foreign pathogen,as a result leading the body to immunosuppressive states.Trend Increase the counts of dendritic cells and improve the ability of antigens presentation and cytokines production may become one of the potential targets for the treatment of sepsis.

关 键 词：脓毒症 树突状细胞 免疫抑制 凋亡 

分 类 号：R459.7[医药卫生—急诊医学]