萘酚喹治疗恶性疟与青蒿琥酯的随机比较  

A Randomized_Controlled Study of Naphthoquine and Artesunate in the Treatment of Falciparum Malaria

作　　者：郭卫中[1] 郑其进[1] 李广谦[1] 欧凤珍[1] 郭兴伯[1] 

机构地区：[1]广州中医药大学热带医学研究所,广州510405

出　　处：《广州中医药大学学报》2000年第3期235-237,共3页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：为评价萘酚喹治疗恶性疟的疗效 ,于 1997年采用磷酸萘酚喹 1d疗程总量 10 0 0mg与青蒿琥酯片 5d疗程总量 6 0 0mg各治疗恶性疟 30例进行随机比较。结果显示 :萘酚喹组平均退热时间为 (2 9.6± 16 .4 )h ,长于青蒿琥酯片组的 (18.3± 9.0 )h (t=3.2 5,P <0 .0 1) ;平均原虫转阴时间萘酚喹组为 (98.4± 2 7.6 )h ,慢于青蒿琥酯片组 (4 3.0± 17.1)h (t=9.4 6 ,P <0 .0 1) ;追踪观察 2 8d ,萘酚喹组治愈率为 96 .7% ,原虫复燃率为 3.3% ,分别高于青蒿琥酯片组治愈率的 73.3% ,低于青蒿琥酯片组原虫复燃率的 2 6 .7% (χ2 =6 .4 0 ,P <0 .0 1)。两组病例除个别出现恶心外 ,未见其他副反应。结果表明 ,磷酸萘酚喹杀灭原虫、控制发热时间较青蒿琥酯慢 ,但治愈率高于青蒿琥酯。To evaluate the effect of naphthoquine in treating falciparum malaria, 60 patients with falciparum malaria were randomly allocated to naphthoquine group (n=30) and artesunate group (n=30) in 1997. Naphthoquine was given for 1 day with a total dose of 1000?mg and artesunate was given for 5 days with a total dose of 600?mg. The mean fever_subsidence time (MFST) was ( 29.6±16.4 )h in naphthoquine group and ( 18.3±9.0 )h in artesunate group (t= 3.25 ,P< 0.01 ). The mean parasite clearance time (MPCT) was ( 98.4±27.6 )h in naphthoquine group and ( 43.0±17.1 )h in artesunate group (t= 9.46 ,P< 0.01 ).The cure rate of naphthoquine group was 96.7% , higher than that of artesunate group( 73.3% ), and recrudescence rate of naphthoquine group within a follow_up period of 28 days was 3.3% , lower than that of artesunate group ( 26.7% ) (χ 2= 6.40 ,P< 0.01 ). No side effects were found except that slight nausea appeared in few patients in both groups. It is concluded that naphthoquine has a shorter MFST and MPCT, and a higher cure rate as compared with artesunate.

关 键 词：恶性疟 药物疗法 萘酚喹 青蒿琥酯 

分 类 号：R531.305[医药卫生—内科学] R978.61[医药卫生—临床医学]