嗜酸粒细胞增多性皮炎五例并文献复习  

Hypereosinophilic dermatitis: 5 cases report and literature review

作　　者：彭世光[1] 曹梅[1] 何焱玲[1] 

机构地区：[1]首都医科大学附属北京朝阳医院皮肤科,北京100020

出　　处：《实用皮肤病学杂志》2013年第3期140-142,共3页Journal of Practical Dermatology

摘　　要：目的探讨嗜酸粒细胞增多性皮炎(HED)的临床特征。方法对2005年以来收治的5例HED患者的临床资料进行回顾性分析,并复习文献,讨论其临床表现与治疗策略。结果 5例患者平均发病年龄65岁,以中老年人为主。皮损类型以红斑、丘疹、结节为主。3例患者行FIP1L1-PDGFRA融合基因检测阴性。5例患者血清IgE均明显升高。中小剂量糖皮质激素和细胞毒类药物对HED治疗有效。免疫调节剂(α干扰素、卡介菌多糖核酸)和生物制剂具有良好疗效。结论早期诊断、个体化治疗及定期随访对HED管理非常重要。Objective To investigate the clinical characteristic of hypereosinophilic dermatitis （HED）. Methods A retrospective study was performed on 5 cases of HED who were treated at our department since 2005. The clinical feature and therapeutic strategy of HED were reviewed based on literature. Results Elderly was the commonest involved group of HED. The major type of lesions was macule, papule and nodule type. FIP1L1-PDGFRA fusion gene of 3 cases who had accepted this test was negative. The level of serum IgE was markedly increased. Slight-moderate dose of corticosteroids and cytotoxic drugs were effective for HED. Immunomodulating agents such as IFN-α and BCG polysaccharide nucleic acid and bio-agents also had efficiency. Conclusion Early diagnosis, individual therapy and scheduler follow-up are important for the management of HED.

关 键 词：皮炎 嗜酸粒细胞增多性 嗜酸粒细胞增多综合征 

分 类 号：R758.69[医药卫生—皮肤病学与性病学]