微生态制剂预防老年抗生素相关性腹泻的临床研究  

Clinical effect of probiotics in the prevention of antibiotic-associated diarrhea in elderlies

作　　者：闫翔[1] 李钰[1] 刘芳[1] 范萍[1] 

机构地区：[1]解放军成都军区总医院老年病科,四川成都610083

出　　处：《中国微生态学杂志》2013年第8期936-938,共3页Chinese Journal of Microecology

摘　　要：目的评价预防性应用微生态制剂（金双歧）在老年人抗生素相关性腹泻中的作用。方法2010年5月至2013年2月应用抗生素的住院老年患者55例纳入观察对象，随机分为2组，预防组28例，给予微生态制剂双歧杆菌乳杆菌三联活菌片（金双歧）4片，3次／d，连续服用7—10d；对照组27例，腹泻患者给予给予思密达3．76g，3次／d。观察两组发生抗生素相关性腹泻情况，并进行肠道菌群分析。结果预防组腹泻发生率、腹泻次数、腹泻持续时间与对照组比较，差异有统计学意义（P〈0．05）。两组腹泻病例的大便培养及常规检查无异常，大便涂片检查出现细菌计数减少或大便杆球菌比失调；预防组粪检结果杆球比例倒置、细菌计数减少、真菌感染例数等与对照组比较差异有统计学意义（P〈0．05）。结论双歧杆菌乳杆菌三联活菌片（金双歧）可预防和减少老年人抗生素相关性腹泻的发生，减轻腹泻症状。Objective To evaluate the prophylactic use of probiotics （Golden Bifid） in the elderly with antibiotic-associated diar- rhea. Methods 55 elderly patients accepted antibiotic treatment from May 2010 to February 2013 were included and randomly divided into 2 groups： prevention group （n = 28 ） was treated with live combined Bifidobaeterium and Laetobacillus （Golden Bifid）, 4 tablets tid for 7-10 days, while the control group （ n = 27 ） was treated with Smecta 3.76 g rid. The two groups were observed for antibiotic-associated diarrhea ; their intestinal microflora were analysed. Results The incidence rate, frequency, and duration of diarrhea in prevention group were significantly different from those in the control group （ P 〈 0.05 ）. No abnormal results of stool culture and conventional examination of diarrhea patients in two groups were observed; fecal smear showed reduced bacterial counts or abnormal ratio of bacillus to coccus. In prevention group, the bacillu/coccus ratio was reversed and bacterial count decreased; the number of fungal infections cases was signifi- cantly different from that of the control group （ P 〈 0.05 ）. Conclusion Live combined Bifidobacterium and Lactobacillus （ Golden Bifid） can prevent and reduce the occurrence of antibiotic associated diarrhea in the elderly, and alleviate the symptoms of diarrhea.

关 键 词：老年人 抗生素相关性腹泻 金双歧 

分 类 号：R574.62[医药卫生—消化系统]