乳果糖联合培菲康预防肝硬化自发性细菌性腹膜炎的疗效观察  

Clinical effect of combination of lactulose and Bifid-triple viable capsule on spontaneous bacterial peritonitis with hepatic cirrhosis

作　　者：沈琦[1] 俞亚峰[2] 

机构地区：[1]绍兴市第六人民医院肝一科,浙江绍兴312000 [2]绍兴市第六人民医院肝二科,浙江绍兴312000

出　　处：《中国微生态学杂志》2013年第8期943-945,共3页Chinese Journal of Microecology

摘　　要：目的探讨乳果糖联合培菲康预防肝硬化自发性细菌性腹膜炎(SBP)的疗效。方法选择肝硬化失代偿期患者186例,随机分为乳果糖与培菲康联合治疗组和常规抗生素治疗组各93例,住院期间同时予以护肝利尿及对症支持治疗,用药3个月进行观察,并采集腹水样本,采用ELISA方法进行TNF-α和IL-6的检测。结果肝硬化患者应用乳果糖与培菲康联合治疗组SBP发生率为12.9%,而常规抗生素治疗组SBP发生率为21.5%,二者间比较差异有统计学意义(P<0.05)。SBP发生患者腹水TNF-α的水平为(1650±126)pg/mL,而未发生SBP为(1312±289)pg/mL,两组间比较差异有统计学意义(P<0.05)。SBP发生患者腹水IL-6的水平为(2566±138)pg/mL,而未发生SBP患者中为(924±251)pg/mL,两组间比较差异有统计学意义(P<0.01)。结论肝硬化患者应用乳果糖联合培菲康可显著降低SBP的发生率。腹水TNF-α和IL-6的水平可监测肝硬化患者SBP的发生。Objective To explore the clinical effect of combination of lactulose and Bifid-triple viable capsule on spontaneous bac- terial peritonitis （SBP） with hepatic cirrhosis. Methods 186 cases of decompensated hepatic cirrhosis were randomly divided into lactu- lose and Bifid-triple viable capsule combination group （ n = 93 ） and conventional antibiotic treatment group （ n = 93 ）. During hospitaliza- tion, all patients were treated with diuretics and supportive treatment. The clinical effect was observed after three months. In addition, the ascites was collected for TNF-α and IL-6 detection using ELISA. Results The incidence of SBP in lactulose and Bifid-triple viable cap- sule combination group was 12.9%, while that in conventional antibiotic therapy group reached to 21.5%, which showed significant difference （P 〈0.05）. The concentration of TNF-α was （1650 ± 126） pg/mL in ascites with SBP while （1312 -±289） pg/mL in aseites without SBP, with a significant difference （P 〈0.05）. The concentration of IL-6 was （2566 ± 138） pg/mL in ascites with SBP while （924 ± 251 ） pg/mL in ascites without SBP, with a significant difference （P 〈 0.05 ）. Condusion The combination of lactulose and Bifid-triple viable capsule could reduce the incidence of SBP significantly. The levels of TNF-αand IL-6 in ascites could be used to moni- tor the occurrence of SBP in patients with cirrhosis.

关 键 词：自发性细菌性腹膜炎 乳果糖 培菲康 肝硬化 

分 类 号：R65[医药卫生—外科学]