中性粒细胞CXCR1、CXCR2活化及其信号传导  

Activation and signal transduction of CXCR1 and CXCR2 on neutrophils

作　　者：韩忠燕[1] 王健[1] 

机构地区：[1]安徽理工大学医学院病原学与免疫学教研室,安徽淮南232001

出　　处：《中国微生态学杂志》2013年第8期975-978,共4页Chinese Journal of Microecology

基　　金：安徽省自然科学基金(090413138);安徽省自然科学基金(1308085MH148);安徽省教育厅自然基金重点项目(KJ2010A086)

摘　　要：中性粒细胞属非特异性免疫细胞,其表面可表达CXCR1和CXCR2。IL-8是其共同配体,它们彼此结合激活后续级联信号传导,产生一系列生物学效应,在介导炎症反应、促进血管新生、维持中性粒细胞稳态等起重要作用。Reparixin是非竞争变构的CXCR1和CXCR2阻滞剂,可抑制中性粒细胞过度趋化、迁移介导的炎症反应。Neutrophils are non-specific immunocytes and can express CXCR1/2 which can activate subsequent cascade signals and produce series of biological effects in inflammatory induction, angiogenesis promotion, and neutrophils homeostasis maintenance by combi- ning with each other＇s common ligands such as IL-$. Reparixin, a typical noncompetitive allosteric inhibitor of CXCR1/2, can play posi- tive inhibitory role in inflammatory response induced by excessive chemotaxis and migration of neutrophils.

关 键 词：中性粒细胞 CXCR1 CXCR2 信号传导 

分 类 号：R37[医药卫生—病原生物学] Q93[医药卫生—基础医学]