巴彦淖尔市医院五年铜绿假单胞菌的分布与耐药性变迁分析  

The analyze of clinical distribution and resistance diversity of Pseudomonas aeruginosa in Bayannaoer city hospital within 5 years

作　　者：吕珂娇[1] 喜贺热[2] 高业[1] 

机构地区：[1]内蒙古巴彦淖尔市医院药剂科,巴彦淖尔市015000 [2]内蒙古巴彦淖尔市医院检验科,巴彦淖尔市015000

出　　处：《实用检验医师杂志》2013年第1期23-25,共3页Chinese Journal of Clinical Pathologist

摘　　要：【摘要】目的分析铜绿假单胞菌（Pseudomonasaeruginosa，PA）分离株的临床分布及耐药性特点，为临床合理用药提供依据。方法对2008—2012年住院患者各类标本分离到的PA的分布及耐药性变迁进行回顾性统计分析。结果398株PA在痰液标本中的检出率最高，为67，09％，其次为脓液和分泌物标本，为25．88％。临床科室的分布中．ICU的检出率最高，为30．90％，其次为呼吸科（14．30％）。PA对常用抗生素的耐药率普遍较高，其中2012年耐药率最高的为氨苄西林／舒巴坦和头孢唑林，均为100．00％，其次为头孢西丁，耐药率为98．70％。头孢哌酮／舒巴坦和左氧氟沙星的用量呈逐年上升趋势，与其耐药率的增长趋势相近。结论PA对常用抗生素的耐药率呈逐年上升趋势且有泛耐药趋势，临床医师应根据药敏结果合理选择抗菌药物，以延缓PA耐药性的产生。Objective To analyze the clinical distribution and drug resistance of Pseudomonas aerug- inosa （PA） and provide the scientific evidence for clinical diagnosis and treatment. Methods Reviewed and analyzed the distribution and drug resistance of PA which isolated from clinical samples from patients during 2008 to 2012 in Bayanner city. Results The highest detection rate of 398 strains PA was sputum samples （67.09%）, the second was pus and secretion samples （25.88%）. In distribution of clinical, the highest detec- tion rate was ICU （30.90%）, the second was respiratory medcine （14.30%）. The detection rates of PA to com- mon antibiotics were almost high. The highest resistant rates in 2012 were ampicillin/sulbactam and cefazolin （100.00%）, the second was cefoxitin （98.70%）. Consumption of cefoperazone/sulbactam and levofloxacin were upward trend, and they were similar to growth of resistant rates. Conclusion The resistant rates of PA to common antibiotics presents an increasing trend. PA strains are mainly multi drug resistant. Rational applica- tion of antibiotic is important for the containment of the drug resistance of PA.

关 键 词：铜绿假单胞菌 耐药性 抗菌药 抗生素 

分 类 号：R378.991[医药卫生—病原生物学]