缬沙坦口腔崩解片的制备及质量评价  

Preparation and Quality Evaluation of Valsartan Orally Disintegrating Tablets

作　　者：张友智[1] 杨晓艳[1] 耿立坚[1] 

机构地区：[1]武汉科技大学附属天佑医院,武汉430064

出　　处：《中国药师》2013年第8期1169-1172,共4页China Pharmacist

摘　　要：目的:制备缬沙坦口腔崩解片,并评价其质量。方法:采用正交设计方法优选出制备的最佳条件,以微晶纤维素、交联聚维酮为崩解剂,制备缬沙坦口腔崩解片。利用高效液相色谱法测定崩解片中缬沙坦的含量。结果:缬沙坦口腔崩解片崩解时间在30 s内,含量稳定。结论:该制备工艺简单、易行,可用于缬沙坦口腔崩解片的制备及质量控制。Objective： To prepare valsartan orally disintegrating tablets and evaluate the quality. Method： The preparation condi- tions of valsartan orally disintegrating tablets were optimized by orthogonal design with microcrystalline cellulose and erosslinked polyvi- nylpyrrolidone as the disintegrating agents. The content of valsartan was determined by HPLC. Result： The disintegration time of the tablets was in 30s, and the content was stable. Conclusion： The preparation process is simple and available, and the methods can be used in the preparation and quality control of valsartan orally disintegrating tablets.

关 键 词：口腔崩解片 缬沙坦 制备工艺 崩解时限 

分 类 号：R944.4[医药卫生—药剂学]