生精胶囊治疗男性不育症Meta分析  

Meta-analysis of Efficacy and Safety of Shengjing Capsules in the Treatment of Male Infertility

作　　者：张小琴[1] 彭金兰[2] 

机构地区：[1]房县人民医院药剂科,湖北房县442100 [2]华中科技大学同济医学院附属普爱医院内分泌科

出　　处：《中国药师》2013年第8期1208-1212,共5页China Pharmacist

摘　　要：目的:评价生精胶囊治疗不育症的临床效果。方法:检索Cochrane-图书馆、Pubmed数据库、CBMdisc数据库、CNKI数据库、VIP数据库、万方数据库,纳入生精胶囊治疗不育症的随机对照试验(RCT),并进行方法学质量评价,采用RevMan5.0软件进行统计分析。结果:共纳入12个RCT。Meta分析结果显示:生精胶囊在提高总有效率[RR=1.38,95%CI(1.02,1.87),P<0.05],改善精子密度[WMD=11.40,95%CI(2.74,20.05),P<0.05]和精子活力(a)[WMD=5.20,95%CI(0.23,10.17),P<0.05]方面明显优于对照组;但其改善精子活率、精子活力(a+b)的效果与对照组差异无统计学意义(P>0.05)。亚组分析表明:生精胶囊在总有效率、精子密度、精子活率、精子活力(a)的效果方面明显优于西药组(P<0.01);但在总有效率、精子密度、精子活力(a+b)的效果方面不及辨证方组(P<0.01或0.05)。生精胶囊与中成药组比较,在总有效率、精子密度、精子活率、精子活力(a+b,a)等方面差异均无统计学意义(P>0.05)。生精胶囊的ADR发生率为0.28%,发生率低且反应程度轻微,均为轻度的胃部不适。结论:基于当前证据,生精胶囊治疗不育症疗效较好,不良反应少,是治疗不育症有效的中成药。Objective： To assess the efficacy and safety of Shengjing capsules in the treatment of male infertility. Method： The studies involving randomized controlled trials （RCTs） were collected from the database, such as the Cochrane Library, Pubmed, CBMdi- sc, CNKI, VIP and Wangfang from the founded year to June 2012. After the necessary methodological quality evaluation of the selected studies ,the statistic analysis was conducted by the software RevMan 5.0. Result： Twelve RCTs were included. The recta-analysis re- sults showed Shengjing capsules in the treatment of male infertility had higher effectiveness than the drugs used in the control groups, which could significantly increase the total effective ratio [ RR = 1.38,95% CI（ 1.02,1.87 ）, P 〈 0.05 ] and improve sperm density [ WMD = 11.40,95 % CI（ 2.74,20.05 ）,P 〈 0.05 ] and sperm vitality （a） [ WMD = 5.20,95 % CI（0. 23,10.17 ）, P 〈 0.05 ], while the sperm motility and sperm sperm vitality（a） showed no statistically significant difference compared with those in the control group（ P 〉 0.05 ）. Subgroup analysis showed the effectiveness of Shengjing capsules on the total effective ratio, sperm density, sperm motility and sperm vitality was obviously superior to the western medicines group（ P 〈 0.01 ） , while inferior to the combined herbs group in the total effective ratio, sperm density and sperm vitality（ a ＋ b） （ P 〈 0.01 or P 〈 0.05 ）. Compared with those in Chinese traditional medicines group, the total efficiency, sperm density, sperm motility and sperm vitality （a ＋ b, a） in Shenjing group showed no statistically signif- icant difference （ P 〉 0.05 ）. The incidence of ADR of Shengjing capsules was 0.28% with mild stomach upset. Conclusion： Based on current evidence, Shengjlng capsules with better curative effect and fewer adverse reactions are effective in the treatment of male infer- tility.

关 键 词：生精胶囊 不育症 有效性 安全性 META分析 

分 类 号：R286[医药卫生—中药学]