氨茶碱对儿童咳嗽变异性哮喘患者炎性指标及肺功能的影响  

Influence of aminophylline on the inflammatory indexes and pulmonary function of children with cough variant asthma

作　　者：孙薇薇[1] 

机构地区：[1]海南省海口市人民医院儿科,570208

出　　处：《中国妇幼保健》2013年第24期3971-3973,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨氨茶碱对儿童咳嗽变异性哮喘患者的炎性指标和肺功能的影响。方法:选取64例儿童咳嗽变异性哮喘患者为研究对象,将所有患者根据随机数字表法分为对照组32例(常规治疗组)和观察组32例(常规治疗加氨茶碱组),对两组患儿治疗前和治疗后1周、2周的血清炎性指标、气道指标、肺功能指标进行检测。结果:治疗后1周和2周观察组的血清炎性指标、气道指标和肺功能指标改善幅度均大于对照组,且观察组治疗后2周检测指标改善幅度大于治疗后1周(P<0.05)。结论:氨茶碱可有效改善儿童咳嗽变异性哮喘患者的炎性状态,并可通过改善气道状态来达到改善肺功能的作用。Objective： To study the influence of aminophylline on the inflammatory indexes and pulmonary function of children with cough variant asthma. Methods： 64 children with cough variant asthma in our hospital were selected as research object, and they were di- vided into control （32 cases, routine treatment group） and observation groups （32 cases, routine treatment and aminophylline group）, then the serum inflammatory indexes, airway indexes and pulmonary function indexes of two groups before and after the treatment at first and second week were detected and compared. Results： The improvement ranges of serum inflammatory indexes, airway indexes and pulmonary function indexes after the treatment at first and second week in observation group were all bigger than those of control group, and those inde- xes of observation group after the treatment at second week were bigger than those after the treatment at first week （ all P 〈 0.05 ） . Conclu- sion： The aminophylline can effectively improve the inflammatory state of children with cough variant asthma, and it can achieve the role of improving the pulmonary function by improving the airway state of patients.

关 键 词：氨茶碱 儿童咳嗽 变异性哮喘 炎性指标 肺功能 

分 类 号：R725.6[医药卫生—儿科]