信号转导与诺贝尔奖  

Signal transduction and Nobel Prize

作　　者：郭晓强[1] 王跃民[1] 

机构地区：[1]中国人民解放军白求恩军医学院生化教研室,讲师石家庄050081

出　　处：《自然杂志》2013年第4期274-285,共12页Chinese Journal of Nature

摘　　要：信号转导是生命科学前沿领域之一,至今已有多项成果荣获诺贝尔奖。从最初的信号分子,到第二信使和可逆磷酸化,再到G蛋白和G蛋白偶联受体,直到今天的信号网络系统,这些研究极大地拓展了人们对生命现象的理解和认识,从而为多种疾病的治疗提供了新的选择。笔者以经典信号通路研究历程为主线,回顾了信号转导研究的发展简史,全面地介绍了诺贝尔奖相关成果的研究背景、历程、意义和应用。Signal transduction is one of frontiers in life sciences, and many achievements in this field were awarded Nobel Prize. From the initial signal molecular to the subsequent second messenger and reversible phosphorylation, to the G-protein and receptor, and until today signal network system, these researches had greatly expanded the understanding of the phenomenon of life and provided new alternative for a lot of diseases. In this article, the brief history of signal transduction is reviewed according to the research course of classical signaling pathway. It is comprehensively introduced including background, history, significance and utilization of Nobel Prize-related achievements.

关 键 词：信号转导 诺贝尔奖 信号分子 受体 G蛋白 第二信使 可逆磷酸化 

分 类 号：R341[医药卫生—基础医学] G321[文化科学]