窒息新生儿尿中IL-8的水平及意义  

THT LEVEL AND IT'S SIGNIFICANCE OF IL-8 IN URINARY OF NEONATES WITH ASPHYXIA

作　　者：肖大成[1] 董文斌[1] 冉隆瑞[1] 唐章华[1] 王胜会[1] 胡晓[1] 陈书琴[1] 

机构地区：[1]泸州医学院附属医院儿科,泸州医学院肾功能保护研究室,646000

出　　处：《新生儿科杂志》2000年第4期150-151,共2页The Journal of Neonatology

基　　金：四川省卫生厅科研基金!资助项目 (编号 980 17)

摘　　要：目的　探讨 IL- 8与新生儿窒息后肾损伤的关系。方法 :采用 EL ISA法检测窒息患儿尿中 IL- 8水平 ,并同时测定尿中反应肾损伤的指标 β2 微球蛋白 (MG)的水平。结果 :轻度窒息组与正常组及重度窒息组与轻度窒息组比较 ,IL - 8、β2 - MG水平显著升高 (P<0 .0 5 ) ,且 IL- 8与 β2 - MG之间呈显著正相关关系 (r=0 .40 ,P<0 .0 5。结论 :尿中 IL- 8水平的测定是判断窒息程度及肾损伤的一个重要指标。To explore the relationship between IL-8 of urinary and postasphyxial renal injury in neonatal asphyxia. Using the level of IL-8 and β 2-MG in urinary were detected in neonates with asphyxia. by using ELISA method. Results showed compared with control, the level of IL-8 and β 2-MG were obviously increased in mild asphyxia group. In severe asphyxia group, the parameters above all were significantly increased compared with mild asphxia group and there were positive relationship between IL-8 and β 2-MG in all neonates with asphxia. Therefore the level of IL-8 in urinary may by regarded as an indicator in evaluating the severity of asphyxia and postasphyxial renal injury in neonates.

关 键 词：新生儿窒息 肾损伤 IL-8 Β2微球蛋白 

分 类 号：R722.1[医药卫生—儿科]