桃红软肝散预防食管静脉曲张出血复发的临床研究  

Prophylaxis of Taohong Softening Liver Granule on the Recurrence in Patients with Esophageal Varieal Bleeding

作　　者：程鹏[1] 徐之德[1] 刘应柯[1] 苗林 彭传辉[1] 刘辉[1] 尹常健[2] 

机构地区：[1]解放军第153中心医院消化内科,郑州450065 [2]山东中医药大学附属医院,济南250011

出　　处：《中国中西医结合脾胃杂志》2000年第4期209-210,共2页

摘　　要：目的 :探讨中药对食管静脉曲张出血复发的预防作用及其机制。方法 :85例食管静脉曲张出血患者止血后随机分为 3组 :中药组 (35例 )、西药组 (2 5例 )和对照组 (2 5例 ) ,中药组和西药组分别给予中药、心得安。结果 :中药组、西药组 1、2年再出血率、2年生存率与对照组比较有显著性差异 (P <0 .0 5 ) ,中药组与西药组无显著性差异 ;治疗前后门静脉内径、脾脏厚度、血清透明质酸的变化有显著性差异 (P <0 .0 5 ) ,中药组脾脏厚度、透明质酸下降高于西药组。结论 :挑红软肝散预防食管静脉曲张出血的疗效与心得安相似 ,其机制可能与防止肝纤维化、降低门静脉压有关。Objective:To assess the effect of Taohong softening liver granule (THSLG) on the recurrence in patients with esophageal varieal bleeding and its mechanism.Methods:After hemorrhage having heen stopped,85 patients with esophageal varieal bleeding were divided into three groups at random.THSLG,propranolol and no drug were given to them respectively.Results:The difference of 1,2 year recurrent rate and 2 year survival rate in three groups were significant,but in THSLG group,propranolol groups were no signifcant.Portal vein diameter, splenic width and serum hyaluronic acid level in propranolol,control groups increased and in THSLG group decreased.The differences were significant.Conclusion:The data indicated that THSLG had marked effect on the recurrence of esophageal varieal bleeding,its mechanism might be relative to its decreasing hepatic fibrosis and portal vein pressure.

关 键 词：食管静脉曲张出血 桃红软肝散 预防 

分 类 号：R259.713[医药卫生—中西医结合]