糖皮质激素联合泛昔洛韦治疗带状疱疹的疗效观察  

Effect of early glucocorticoid combined with famciclovir on herpes zoster patients

作　　者：周动机[1] 胡毅强[1] 

机构地区：[1]开平市中心医院皮肤科,广东开平529300

出　　处：《中国热带医学》2013年第7期889-891,共3页China Tropical Medicine

摘　　要：目的探讨早期小剂量应用糖皮质激素治疗带状疱疹的最佳疗程及安全性。方法选择145例带状疱疹患者,随机分为观察组75例和对照组70例,两组均常规口服泛昔洛韦、甲钴胺;肌注维生素B1、B12;外用炉甘石洗剂,疗程为9d。观察组在此基础上口服小剂量泼尼松,观察其最佳有效疗程及安全性。结果观察组在止痛、止疱、结痂、皮损痊愈时间明显优于对照组(P<0.05);观察组和对照组相比疼痛缓解积分及后遗神经痛的发生率明显降低(P<0.05)。但9天时两组的疼痛缓解积分则无差异性(P>0.05)。安全性方面两组均无明显的不良反应(P>0.05)。结论早期应用糖皮质激素治疗带状疱疹安全有效,疗程以6天内为最佳。Objective To observe the effect and safety of early low-dose glucocorticoids and famciclovir on herpes zoster patietns.Methods The 145 herpes zoster patients were collected and randomly divided into the observation groups of 75 cases and control groups of 70 cases. Both groups were treated with conventionally oral famciclovir, mecobalamin; intramuscular injection of vitamin B1, B12; topical calamine lotion for 9 days. While low-dose oral prednisone was added to those in observation grou, The effect and safety in bbth groups were analyzed.Results The analgesia, blister clearance, scabbing and skin lesions healed time were significantly faster than that of the control group （P〈 0.05） ; Compared to the control group the pain Relief credits and the incidence of postherpetic neuralgia in the observation group were significantly reduced （P 〈 0.05）. But no significant difference was noticed in pain relief credits 9 days after treatment between the two groups（P 〉 0.05 ）,also there were no obvious adverse reactions of safety were found（P〉 0.05）.Conclusion Early application of glucoeorticoid and famciclovir in treatment of herpes zoster patients is safe and effective, within 6 days is advocated.

关 键 词：糖皮质激素 泛昔洛韦 带状疱疹 安全性 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]