Tetraamido-oxacalix[4]arene Derivatives： Synthesis, Structures and Supramolecular Assemblies  

作　　者：Lingwei Kong Mingliang Ma Xiaoli Zhao Yahua Liu Xianqiang Mi Biao Jiang Ke Wen 

机构地区：[1]~hanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Nor- mal University, Shanghai 200062, China [2]Shanghai Key Laboratory of Green Chemistry and Chemical Processes, and Department of Chemistry, East China Normal University, Shanghai 200062, China [3]Medicinal Chemistry, ChemBridge Research Laboratories Inc., San Diego, CA 92127, USA [4]Sustainable Technology Research Center, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201203, China

出　　处：《Chinese Journal of Chemistry》2013年第5期684-688,共5页中国化学（英文版）

基　　金：Financial support from National Natural Science Foundation of China，Shanghai Commission for Science and Technology，"Strategic Priority Research Program" of the Chinese Academy of Sciences (No.XDA01020304) is acknowledged

摘　　要：Tetraamido-oxacalix[4]arene derivatives have been synthesized via the reactions of tetraamino-oxacalix[4]arene with excess butyryl chloride, octanoyl chloride, benzoyl chloride and p-toluenesulfonyl chloride, respectively. JH NMR results suggest that these oxacalix[4]arene derivatives preferentially adopt the 1,3-alternate （saddle-like） con- formation in solution, which were also the case in the solid state as demonstrated by single crystal X-ray analysis. A dimerized slipped capsule could be formed by tetra-butyramido-oxacalix[4]arene in the solid state via intermolecu- lar hydrogen bond interactions under the assistance of two encapsulated methanol molecules. On the other hand, a molecular cavity was formed by tetra-p-toluenesulfonamido-oxacalix[4]arene which can encapsulate a solvent molecule of ethyl acetate.Tetraamido-oxacalix[4]arene derivatives have been synthesized via the reactions of tetraamino-oxacalix[4]arene with excess butyryl chloride, octanoyl chloride, benzoyl chloride and p-toluenesulfonyl chloride, respectively. JH NMR results suggest that these oxacalix[4]arene derivatives preferentially adopt the 1,3-alternate （saddle-like） con- formation in solution, which were also the case in the solid state as demonstrated by single crystal X-ray analysis. A dimerized slipped capsule could be formed by tetra-butyramido-oxacalix[4]arene in the solid state via intermolecu- lar hydrogen bond interactions under the assistance of two encapsulated methanol molecules. On the other hand, a molecular cavity was formed by tetra-p-toluenesulfonamido-oxacalix[4]arene which can encapsulate a solvent molecule of ethyl acetate.

关 键 词：arene SYNTHESIS ASSEMBLY MACROCYCLE 

分 类 号：TQ028.5[化学工程] TB383[一般工业技术—材料科学与工程]