分子筛OMS-2负载铜催化(3R,4R)-3-[1'R-叔丁基二甲基硅氧乙基]-4-乙羧基-1-对甲氧基苯基-2-氮杂环丁酮脱羧乙酰氧基化的性能研究  

Decarboxylation-acetoxylation of (3R,4R)-4-acid3-{ 1'R-[(t-butyl-dimethylsilyl)oxy]-ethyl}-1-methoxyphenyl-2-azetidinone catalyzed by Cu-OMS-2 with NaBrO_3/NaOAc

作　　者：彭兵兵[1] 唐鹤 周军荣[1] 

机构地区：[1]兰州理工大学石油化工学院,甘肃兰州730050 [2]浙江海翔川南药业有限公司,浙江台州318000

出　　处：《工业催化》2013年第6期66-70,共5页Industrial Catalysis

摘　　要：在Cu-OMS-2分子筛催化下,进行(3R,4R)-3-[1'R-叔丁基二甲基硅氧乙基]-4-乙羧基-1-对甲氧基苯基-2-氮杂环丁酮脱羧乙酰氧基化的研究,考察Cu负载量、氧化剂、反应温度以及反应时间等因素对催化效果的影响。结果表明,在Cu负载质量分数为4.15%、NaBrO3作为氧化剂、反应温度65℃和反应时间3 h条件下,分离收率最佳为83%。（ 3R, 4R ）4-acetoxy-3-{ 1＇ R-[ （ t-butyl-dimethylsilyl ） oxy ]-ethyl } -1-methoxyphenyl-2-azetidinone, an important precursor for the synthesis of carbapenem antibiotics, was synthesized by using Cu-OMS-2 molecular sieve as the catalyst. The influence of Cu loadings,oxidant kinds ,reaction temperatures and reaction time was investigated. The results showed that the optimal yield of 83% was attained under the condition as follows ：Cu loading mass fraction 4.15% ,NaBrO3 as the oxidant,reaction temperature 65℃ and reaction time 3 h.

关 键 词：精细化学工程 Cu-OMS-2分子筛 (3R 4R)-3-[1'R-叔丁基二甲基硅氧乙基]-4-乙羧基-1-对甲氧基苯基-2-氮杂环丁酮脱羧 乙酰氧基化 

分 类 号：TQ426.6[化学工程] O643.36[理学—物理化学]