莫西沙星治疗老年人慢性阻塞性肺疾病急性发作的疗效  

Clinical evaluation of moxifloxacin on acute exacerbation of chronic obstructive pulmonary disease in elderly patients

作　　者：杨庆宇[1] 梁冰[1] 周海艳[1] 潘攀[1] 

机构地区：[1]蚌埠医学院第一附属医院老年病科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2013年第6期663-665,共3页Journal of Bengbu Medical College

摘　　要：目的:评价莫西沙星治疗老年人慢性阻塞性肺疾病急性发作(AECOPD)的疗效及安全性。方法:将78例AECOPD患者随机分为2组,对照组(38例)予左氧氟沙星0.4 g(每天1次),静脉滴注;观察组(40例)予莫西沙星0.4 g(每天1次),静脉滴注;2组疗程均为7～14 d,观察临床总有效率、细菌清除率及不良反应发生率。结果:观察组总有效率为87.5%,对照组总有效率为73.7%,差异有统计学意义(P<0.05)。观察组细菌清除率为90.5%,不良反应发生率为7.5%,对照组细菌清除率为58.8%,不良反应发生率为10.5%,差异均无统计学意义(P>0.05)。结论:莫西沙星治疗老年人AECOPD临床疗效肯定。Objective： To evaluate the efficiency and safety of moxifloxacin on acute exacerbation of chronic obstructive pulmonary disease（AECOPD） in elderly patients. Methods：Seventy-eight elderly patients with AECOPD were randomly divided into observation group and control group. In control group,38 patients were treated with levofloxacin at 0.4g, intravenous infusion, one time per day;The 40 patients in observation group were treated with moxifloxacin at 0.4g, intravenous infusion, one time per day;the treatment lasted 7 - 14 days in the two group,the total effective rate,bacterial eradication rate and drug reaction were compared between the two groups. Results：In moxifloxacin group, the effective rate was 87.5% ,in levofloxacin group, the effective rate was 73.7%, there had statistical differences（P 〈 0.05）. The bacterial eradication rate and adverse drug reaction rate were 90.5% and 7.5% in moxifloxacin group vs 58.8% and 10.5% in levofloxacin group, which had no statistical differences（ P 〉 0.05 ）. Conclusions： Moxifloxacin is an effective and safe drug in treatment of AECOPD in elderly patients.

关 键 词：肺疾病 阻塞性 莫西沙星 左氧氟沙星 老年医学 

分 类 号：R563.9[医药卫生—呼吸系统]