老年高血压患者血压变异性与其血浆血管性血友病因子和D-二聚体的关系  

Correlation among blood pressure variability, von willebrand factor and D-dimer in elderly hypertensive patients

作　　者：王乃玲[1] 茅娟 孙宝玲[1] 

机构地区：[1]上海市浦东新区浦南医院心血管内科,200125

出　　处：《蚌埠医学院学报》2013年第6期732-734,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨老年原发性高血压患者血压变异性与其血浆血管性血友病因子(vWF)和D-二聚体的关系。方法:随机选择年龄≥60岁的老年原发性高血压患者100例(高血压组)和老年健康体检者100名(对照组),检测2组血压变异性、血浆vWF和D-二聚体水平。结果:高血压组血压变异性均显著高于对照组(P<0.01);高血压组血浆vWF水平显著高于对照组(P<0.01);高血压组24 h收缩压变异性与血浆vWF水平呈正相关关系(P<0.05)。结论:老年原发性高血压病患者血压变异性显著增高,并伴有血浆vWF水平升高,提示血管内皮功能损伤。Objective：To investigate the association among blood pressure variability, plasma von willebrand factor （vWF） and D- dimer levels in elderly patients with essential hypertension. Methods：One hundred cases whose age over 60 years with essential hypertension（hypertension group） and 100 cases of healthy elderly controls（ control group） were randomly recruited into study. The blood pressure variability during 24 hours was monitored and plasma vWF and D-dimer levels were measured for each patient in both groups. The associations between blood pressure variability and plasma vWF and D-dimer levels were analyzed in each group respectively. Results：The blood pressure variability during 24 hours in hypertension group were significantly higher than that in control group（ P 〈 0.01 ）. The plasma vWF level in hypertension group was significantly higher than that in control group（ P 〈 0.01 ）. The plasma vWF level was positively correlated with 24 hours systolic blood pressure variability in hypertension group （ P 〈 0.05 ）. Conclusions：Blood pressure variability in hypertension patients with essential hypertension was increased obviously, accompanied with the increase of Dlasma vWF level,which imolvinz the potential imDairment of vascular endothelium.

关 键 词：高血压 血压变异性 血管性血友病因子 D-二聚体 

分 类 号：R544.1[医药卫生—心血管疾病]