咬肌神经切除和化学去神经对大鼠下颌骨骨密度的影响  

Effect of neurectomy and chemodenervation of the masseter muscle on mandibular bone mineral density

作　　者：黄进军[1] 柳大烈[2] 耿健[3] 王晋煌[2] 

机构地区：[1]中国人民解放军105医院整形美容中心,合肥230031 [2]南方医科大学珠江医院整形美容外科 [3]第四军医大学西京医院整形外科

出　　处：《中华医学美学美容杂志》2013年第4期291-294,共4页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的探讨咬肌神经切除和化学去神经对大鼠下颌骨骨密度的影响。方法以28d龄Wistar大鼠为实验模型。实验分为4组：手术1组：切除右侧咬肌神经；手术2组：显露但不切除右侧咬肌神经；肉毒毒素组：右侧咬肌肌内注射A型肉毒毒素；对照组：仅麻醉。75d时取各组双侧完整下颌骨，用双能x线骨密度仪测量感兴趣区的骨密度。结果大鼠下颌骨骨密度（BMD）：手术1组左侧为（0．184士0。012）g／cm2，右侧为（0．184±0．026）g／cm2；手术2组左侧为（O．179±0．022）g／cm2，右侧为（0．173±0．019）g／cm2；肉毒毒素组左侧为（0．165±0．061）g／cm2，右侧为（0．158±0．051）g／cm2；对照组左侧为（O．196±0．026）g／cm2，右侧为（0．185±0．022）g／cm2。组问左右侧差异均无统计学意义（P〉0．05）；右侧下颌骨BMD组间比较：手术1组、手术2组和对照组差异无统计学意义（P〉0．05），肉毒毒素组和对照组差异无统计学意义（P〉0．05）。结论切除幼龄大鼠咬肌神经、咬肌肌内注射A型肉毒毒素，对成年后下颌骨骨密度无明显影响。Objective To evaluate the effect of neurectomy and chemodenervation of the masse- ter muscle on mandible bone mineral density. Methods Thirty 28-day-old Wistar rats were divided in- to four groups： operation groups 1 and 2, botulinum toxin group and control group. The main trunk and initial branches of masseteric nerve on the right side were resected in the operation group 1. The nerve was exposed, but not resected in the operation group 2. The right side of masseter muscle was injected with botulinum toxin type A and the left side was injected with sterile saline in botulinum toxin group when the rats were 28 days old. The control group was only anaesthetised. Bilateral man- dibles of all four groups were scanned by GE lunar prodigy bone densitometer when the rats were 75 days old. Results BMD was （0. 184±0. 012） g/cm2 on the left side and （0. 184±0. 026） g/cm2 on the right side in operation group 1. BMD was （0. 179±0. 022） g/cm2 on the left side and （0. 173± 0. 019） g/cm2 on the right side in operation group 2. BMD was （0. 165±0. 061） g/cm2 on the left side and （0. 158±0. 051） g/cm2 on the right side in botulinum toxin group. BMD was （0. 196± 0. 026） g/cm2 on the left side and （0. 185±0. 022） g/cm2 on the right side in control group. The vari- ance of BMD between two sides of each group was not significant difference. The variances of BMD among the right side of the four groups were not significant difference. Conclusions No pathological changes in mandibular bone mineral density after denervation and chemodenervation of the masseter muscle are observed in this study.

关 键 词：下颌骨 神经切除术 A型肉毒毒素 骨密度 

分 类 号：R622[医药卫生—整形外科]