SOD络合铜对氟性肾损伤拮抗作用—亚显微结构研究  

Substructure study of antagonism of MSOD copper in kidney damaged with fluorosis

作　　者：张莉[1] 王志成[2] 李红[1] 富德[2] 边晓燕[1] 廖展如[3] 阎景龙[2] 管春鹏 

机构地区：[1]哈尔滨医科大学电镜室,黑龙江哈尔滨150086 [2]哈尔滨医科大学第二临床医学院骨科,黑龙江哈尔滨150086 [3]华中师范大学化学系,湖北武汉430079

出　　处：《中国地方病学杂志》2000年第5期335-336,共2页Chinese Jouranl of Endemiology

基　　金：国家自然科学基金!(39470 6 32 )

摘　　要：目的　探讨氟毒作用后 ,活性氧自由基对大鼠肾组织损伤的超微病理变化及人工合成的超氧化物歧化酶对肾脏的保护作用。方法　选用 40只大鼠随机分为 4组 ,1正常对照组 :自由饮用自来水 ;2氟中毒组 :饮用 10 0 m g/L氟化钠 ;3治疗组 :饮用相同浓度的氟化钠同时腹腔注射络合酮 ;4治疗对照组 :饮氟同时食入硼。 5个月后处死做透射电镜观察。结果　氟中毒组 ,肾小管微绒毛排列紊乱 ,脱失。胞膜基底褶变平 ,乃致细胞膜破裂。治疗组 ,注入 SOD模型配合物络合酮后 ,大鼠肾组织超微结构基本正常。结论　活性氧自由基参与了肾组织的超微病理变化 。Objective To explore after fluorosis,free radicals of active oxygen to kidney tissue injury is changing ultrastrcture pathological and the kidney injury is protected on mechanism by model superoxide dismutase (MSOD) from the mixture of artificial.Methods Forties westar rats were divided randomly into 4 groups;①The control group:drinking nomal tap water;②Fluorosis group:drinking fluoride (NAF/100 mg/L);③Cure group:dinking water containg the same amount of fluoride as fluorosis group,but giving casein copper;④Control of cure group:drinking the same amount of fluoride as bring borax.Results Microvilli arranged in disorederscaled off and lost normal structure in the proximal tubule.Conclusions Free radical was involved in ultrastructure changes of kidney,and MSOD copper exerted protect effect.

关 键 词：氟中毒 肾损伤 络合酮 亚显微结构 SOD 

分 类 号：R599.906[医药卫生—内科学] R692.02[医药卫生—临床医学]