国产司帕沙星与洛美沙星治疗急性细菌性感染的随机对照研究  

A Rɑndomized Controlled Clinicɑl Study on Domestic Spɑrfloxɑcin Compɑred

作　　者：苗佳[1] 梁德荣[1] 徐楠[1] 郑莉[1] 张辉明[1] 

机构地区：[1]华西医科大学附属第一医院临床药理研究所,成都610041

出　　处：《华西医学》2000年第3期300-303,共4页West China Medical Journal

摘　　要：为评价国产司帕沙星片的临床疗效与安全性 ,采用洛美沙星片为对照 ,共治疗急性细菌性感染 70例 ,其中试验组与对照组各 35例。司帕沙星 2 0 0mgQD ,洛美沙星 30 0mgBid ,疗程 7～ 14日。结果显示 ,试验组和对照组的临床痊愈率均为 80 0 0 % ,有效率分别为 94 2 9%和 97 14% ,细菌清除率分别为 93 94%和 93 75 % ,不良反应发生率分别为 8 75 %和 5 71%。以上结果两组比较均无统计学差异 (P >0 0 5 )。本研究表明 ,国产司帕沙星片治疗急性细菌性感染安全、有效 ,且使用简便、日仅用药一次。WT5”BZ]A randomized controlled clinical trial was conducted to evaluate the efficacy and safety of domestic sparfloxacin in comparison with lomefloxacin in the treatment of acute bacterial infections.Total of 70 patients entered the study.Each group involved 35 cases.Sparfloxacin 200mg orally once daily and lomefloxacin 300mg orally twice a day for 7～14 days.The results showed that the clinical cure rates of both groups were 80 00%.The efficacy rates,the bacterial clearance rates and the adverse reaction rates of sparfolxacin and lomefloxacin were 94 28%,97 14%;93 94%,93 75% and 8 57%,5 71% respectively There was no statistical difference between the two controlled groups( P>0 05 ).This study indicates that domestic sparfloxacin is effective and safe in treating acute bacterial infections.It is very convenient to use it once a day. [WT5”HZ]

关 键 词：司帕沙星 洛美沙星 急性细菌性感染 药物治疗 

分 类 号：R96[医药卫生—药理学]