肌钙蛋白抬高对COPD急性加重患者的影响  

The effectof cardiac troponin Televated on patients with COPD acute exacerbation

作　　者：张军[1] 赵菲[1] 潘晓明[1] 

机构地区：[1]中国医科大学附属第四医院呼吸内科,辽宁沈阳110005

出　　处：《中国医学工程》2013年第5期27-28,共2页China Medical Engineering

摘　　要：目的慢性阻塞性肺疾病(COPD)和右心室负荷增加及肺动脉高压有密切的联系。我们的目的是评价血浆肌钙蛋白抬高对COPD急性加重患者预后的影响。方法对2010-2011年我院COPD急性加重的住院患者资料进行回顾性的研究。551名患者在入院48 h进行了cTnT检测。血浆肌钙蛋白大于或等于0.04 ug/l,被认为肌钙蛋白抬高,临床资料从患者记录中被检索。结果 154名患者(28%)血浆肌钙蛋白抬高,cTnT增高的同时观察到中性粒细胞数、肌酸酐浓度、心率增高及血红蛋白浓度降低。血浆肌钙蛋白水平增高与患者死亡率增加有明显的联系。结论 COPD急性加重患者的血浆肌钙蛋白抬高与多种因素改变有关,特别与炎症感染加重有关,并且增加了患者的死亡危险.[ Objective ] Chronic Obstructive Pulmonary Disease （COPD） is associated with rightventricular loading and pulmonary hypertension. We aimed to evaluate the effectof cardiac troponin Televated on patients with COPD acute exacerbation. [ Methods ] Retrospective cohortstudy with analysis of admissions for acute exacerbation of COPD in 2010-2011, 551 had measurementof cTnTperformed in the first48 hours of admission. Levels of cTnT I〉 0.04ug/1 were considered elevated. Clinical and historical data were retrieved from patientrecords, hospital and laboratory databases. In- hospital mortality were analysised. [ Resluts ] Elevated cTnTlevels was observated in 154 patients （28%）. We observated increasing neutrophil count, creatinine concentration, heartrate and decreasing hemoglobin concentration, associated with elevated cTnT. Elevated cTnTlev cTnTlevels in patients with acute and increased risk of death. els was significantly associated with high in-hospital mortality. [ Conclusion ] Elevated exacerbation was associated with multiple factors, especially with exaggerated infection,

关 键 词：慢性阻塞性肺疾病 肌钙蛋白 死亡率 

分 类 号：R563[医药卫生—呼吸系统]