肌肉生长抑制素基因在不同动物中的研究进展  

Research Progress on Myostatin(MSTN) Gene in Different Animals

作　　者：李盈[1] 额尔敦木图[1] 刘图雅 伊特格勒图 沙日扣 图雅 

机构地区：[1]内蒙古农业大学兽医学院,农业部动物疾病临床诊疗技术重点实验室,内蒙古呼和浩特010018 [2]内蒙古阿拉善左旗兽医局,内蒙古巴彦浩特750300 [3]内蒙古阿拉善左旗乌力吉苏木动物卫生监督站,内蒙古巴彦浩特750322 [4]内蒙古阿拉善左旗银根动物卫生监督站,内蒙古巴彦浩特750323 [5]内蒙古阿拉善农牧业综合行政执法支队,内蒙古巴彦浩特750306

出　　处：《中国畜牧兽医》2013年第8期141-145,共5页China Animal Husbandry & Veterinary Medicine

摘　　要：肌肉生长抑制素(myostatin,MSTN)基因也叫生长分化因子(growth differentiation factor-8,GDF8),其作为肌肉生长发育及分化的负向调控因子,可通过抑制正向调控因子———生肌决定因子(myogenic determination gene,MyoD)的转录活性来抑制成肌细胞的增殖和分化。MSTN基因在进化过程中具有较高的突变性,在不同动物中的表达量和表达范围均不相同。作者就该基因的表达、生物学功能、作用机制及在不同动物中的研究进展进行了详细阐述。Myos^tin（MSTN）, also called growth differentiation factor-8 （GDF-8）, could restrain the proliferation and dif- ferentiation of skeletal myoblasts through restraining the transcriptional activity of the positive regulation factor（myogenic de- termination gene） as the negative regulation factor of the growth and differentiation on muscle. MSTN gene had high mutation during evolution. In addition, its quantity and range of expression were different on different animals. Its expression, biology function, mechanism of action and research progress on different animals were el＇aborated in this paper.

关 键 词：肌肉生长抑制素 表达 单核苷酸多态性位点 

分 类 号：S852.23[农业科学—基础兽医学]