黄连碱药理活性研究进展  

Advance in studies on pharmacological activity of coptisine hydrochloride

作　　者：张志辉[1] 邓安珺[1] 于金倩[1] 李志宏[1] 吴练秋[1] 王文杰[1] 秦海林[1] 

机构地区：[1]中国医学科学院北京协和医学院药物研究所,天然药物活性物质与功能国家重点实验室,北京100050

出　　处：《中国中药杂志》2013年第17期2750-2754,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81373269,81202546)

摘　　要：黄连碱是一种天然的原小檗碱型生物碱季铵盐,存在于毛茛科和罂粟科的多种植物中,资源丰富。尽管有关黄连碱的药理研究还不深入,但已有文献报道其有抑制A型单胺氧化酶、选择性抑制和双重抑制血管平滑肌细胞增殖、抑制破骨细胞分化和功能、选择性调节血管平滑肌细胞中的多药耐药蛋白质、抗真菌、胃黏膜保护、细胞毒、心肌保护等一些药理活性。鉴于目前缺少对黄连碱研究的系统回顾和综述,该文对近年来发表的黄连碱药理活性研究文献进行整理和分析,为深入开展以药理活性为基础的黄连碱创新药物研究提供信息。Coptisine hydrochloride, as a natural protoberberine alkaloid quaternary ammonium salt, can be found in many spe-cies of Ranunculaceae and Papaveraceae plants. Despite no in-depth studies on coptisine hydrochloride, some literatures have reported that coptisine hydrochloride has such pharmacological activities as inhibition of monoamine oxidase of type A, selective inhibition and double inhibition against vascular smooth muscle cell proliferation, inhibition of differentiation and function of osteoclasts, selective reg- ulation of muhidrng-resistant and drug-resistant proteins in vascular smooth muscle cells, anti-fungus, protection of gastric-mucous membrane, cytotoxicity, and myocardial protection. Given to the fact of the lack of systematic review and summary of studies on cop-tisine hydrochloride, we summarize and analyze the study literatures on the pharmacological activity of eoptisine hydrochloride pub-lished in recent years, so as to provide information for studies on new drugs of eoptisine hydroehloride on the basis of the pharmacologi-cal activity.

关 键 词：黄连碱 药理活性 研究进展 

分 类 号：R285[医药卫生—中药学]