人参皂苷CompoundK注射液免疫毒性评价  

Immunotoxicity study of Ginenoside Compound K Injection

作　　者：宋超[1] 董鲁平 李淑珍[1] 

机构地区：[1]山东省交通医院药剂科,济南250031

出　　处：《国际中医中药杂志》2013年第9期789-791,共3页International Journal of Traditional Chinese Medicine

摘　　要：目的评价人参皂苷CompoundK注射液的免疫毒性。方法采用主动全身过敏试验、被动皮肤过敏试验对人参皂苷CompoundK注射液的免疫毒性进行评价。结果主动全身过敏试验中，阳性对照过敏反应呈极强阳性，人参皂苷CompoundK注射液的高、低剂量组均未见过敏反应，各组豚鼠的体重变化未见明显差异。被动皮肤过敏试验中，阳性对照组各动物均出现蓝斑，且直径〉5mm，左侧蓝斑直径（10．1±3．34）mm，右侧蓝斑直径（7．57±1．94）mm，血清培E含量明显增高（P〈0．01），人参皂苷CompoundK注射液的高、低剂量组均未出现直径〉5mm的蓝斑，血清IgE含量未见明显改变。结论人参皂苷CompoundK注射液在该实验条件下未见免疫毒性。Objective Evaluate the immunotoxicity of Ginenoside Compound K Injection. Methods Active Systemic Anaphylaxis （ASA）tests and Passive Cutaneous Anaphylaxis （PCA）tests were used to evaluate Ginenoside Compound K Injection. Results In the ASA tests, positive control group showed pole-strength anaphylaxis, both the high-dose group and the low-dose group of Ginenoside Compound K Injection didn＇t produce allergic reaction and the body weights of all groups showed no significant differences. In the PCA tests, all rats of positive control group caused blue spots with their diameters bigger than 5 mm （diameters on the left side of blue spots was（10.1 _3.34）mm and diameters on the right side of blue spots was （7.57___ 1.94）mm. Serum IgE was significantly increased. While both high dose and low dose of Ginenoside Compound K Injection group didn＇t show blue spots with their diameters greater than 5 mm and their IgE levels showed no significant differences compared with negative control group. Conclusion Ginenoside Compound K Injection showed no immunotoxicity under these experimental conditions.

关 键 词：人参皂苷CompoundK注射液 主动全身过敏试验 被动皮肤过敏试验 

分 类 号：R285.5[医药卫生—中药学]