白玉散联合经方医药治疗不同证型黄褐斑患者临床研究  

A clinical research of combination Baiyu Powder with classical prescription medicine for treatment of patients with different syndromes of chloasma

作　　者：罗秋红[1] 覃永健[1] 钟江[1] 黄云淑[1] 黄为阳[1] 黄在英[1] 刘丽婷[1] 

机构地区：[1]广西中医药大学第一附属医院皮肤科,广西南宁530023

出　　处：《右江民族医学院学报》2013年第4期444-446,共3页Journal of Youjiang Medical University for Nationalities

基　　金：广西自然科学基金课题(编号:2011GXNSFA018217)

摘　　要：目的对比局部外敷白玉散联合经方医药口服治疗不同证型黄褐斑患者的临床效果。方法治疗组与对照组黄褐斑患者依据证型分为肝郁气滞证、肝肾阴虚证、脾虚湿热证、气滞血瘀证组,治疗组各个证型患者采用白玉散外敷每周2次同时辨证施治口服经方医药分别为:丹栀逍遥散、六味地黄汤、参苓白术散、桃红四物汤,对照组依据证型口服经方医药同治疗组,两组均为每日一剂水煎服,4周为1个疗程,3个疗程后对比观察疗效。结果经成组设计两样本比较的秩和检验,治疗组与对照组疗效比较差异有统计学意义(z=-5.24,P<0.001),治疗组疗效好于对照组。经成组设计多样本比较的秩和检验,治疗组中各证型间疗效总的说来,差异有统计学意义(χ2=8.39,P=0.039),经采用扩展t检验进行两两比较,肝郁气滞证、脾虚湿热证、气滞血瘀证组的疗效均好于肝肾阴虚证组;肝郁气滞证、脾虚湿热证、气滞血瘀证组3个组间疗效的差异无统计学意义。同一证型疗效的比较,治疗组与对照组肝郁气滞证组、脾虚湿热证组、气滞血瘀证组疗效差异有统计学意义,治疗组好于对照组;肝肾阴虚证在治疗组与对照组疗效差异无统计学意义(P>0.05)。对照组中各证型间疗效的差异无统计学意义(χ2=2.19,P=0.534)。结论白玉散联合经方医药治疗肝郁气滞证、脾虚湿热证、气滞血瘀证黄褐斑患者效果较好。Objective To Comparison of clinical curative effect of combination Baiyu Powder with classical prescription medicine for treatment of patients with different syndrome chloasma. Methods According to different syndromes, patients in the treatment group and the control group had been sub--grouped： syndrome of liver depression and qi stagnation group, liver--kidney yin deficiency syndrome group, syndrome of spleen deficiency and dampness heat group, syndrome of qi stagnation and blood stasis group, separately. In the treatment group, patients had externally received Baiyu Powder twice a week, additionally, corresponding to the four above syndrome sub--groups, patients had also been given orally the four following classical prescription or recipe medicine： Danzhi Xiaoyao San, Rehmanniae Decoction of Six Ingredients, Shenling Baizhu Powder, Tao Hong Si Wu Tang. In the control group, patients received the same classical prescription medicine similarly to the treatment group. Both the two groups received orally one dose of decoction once a day, four weeks for a cycle. After three cycles,the therapeutic effect was observed and compared. Results The group designed rank sum test was used to evaluate the difference of curative effect between the treatment group and the control group, there was statistical significant difference（ z =--5.24, P d0. 001）,the curative effect of the treatment group was better than the control group. The diverse rank sum test was used for group designed samples comparison： in the treatment group, the comparison of curative effect among every two syndrome sup--groups had been done, there were statistical significant difference （X^2 =8.39, P =0. 039）, the expansion t test of two-- sample comparison had also been done, the curative effect in syndrome of liver depression and qi stagnation group, in syndrome of spleen deficiency and dampness heat group, syndrome of qi stagnation and blood stasis group were better than liver--kidney yin deficiency syndrome group~ comparison of curative effe

关 键 词：白玉散 经方 黄褐斑 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]