粉防己碱对糖尿病性勃起功能障碍大鼠勃起功能的影响  

Effect of Tetrandrine on Erectile Function of Rats with Diabetic Erectile Dysfunction

作　　者：郭燕东[1] 冯钢[1] 李天杨[1] 炜青[1] 孙利群[1] 吴琼伟[1] 

机构地区：[1]广州医学院附属第五医院泌尿外科,广东广州510700

出　　处：《湖北民族学院学报（医学版）》2013年第2期37-39,共3页Journal of Hubei Minzu University(Medical Edition)

基　　金：广东省中医药局课题(20111265)

摘　　要：目的探讨粉防己碱(tetrandrine,Tet)对糖尿病性勃起功能障碍大鼠勃起功能的影响及机制。方法 24只糖尿病性勃起功能障碍(Erectile dysfunction,ED)大鼠随机分为Tet组(n=8)、罂粟碱组(n=8),另选取8只大鼠作为阴性对照组,Tet组和罂粟碱组分别在阴茎海绵体注射Tet和罂粟碱,阴性对照组注射等容量生理盐水,观察各组大鼠阴茎海绵体内压的改变以及环磷酸腺苷(cAMP)的变化,观察各组阴茎勃起次数和勃起率的改变。结果罂粟碱组和Tet组阴茎海绵体内压和cAMP含量明显高于阴性对照组(P<0.05),ED对照组、罂粟碱组和Tet组平均勃起次数和勃起率均明显低于阴性对照组(P<0.05或P<0.01)。结论 Tet行阴茎海绵体注射可有效松弛阴茎海绵体平滑肌,改善阴茎勃起功能,其机制可能与提高阴茎海绵体内cAMP含量有关。Objective to explore the effect and mechanism of tetrandrine on erectile function of rats with diabetic erectile dysfunction. Methods 24 rats with with diabetic erectile dysfunction （ED） were randomly divided into tetrandrine group （n=8）, papaverine group （n=8） and ED control group. The corpus cavernosum penis was respectively injected with tetrandrine and pa- paverine in the tetrandrine group and papaverine group and the normal control group and ED control group were injected with saline.We observed the changes of nitric oxide （NO）, nitric oxide synthase （NOS） and cyclic adenosine monophosphate （cAMP） of the corpus caverno- sum penis and the times and rate of erection.Results The content of nitric oxide （NO）, nitric ox- ide synthase （NOS） and cyclic adenosine monophosphate （cAMP） in the ED control group, papaverine group and Tet group decreased significantly （P〈0.05）. The content of nitric oxide （NO）, nitric oxide synthase （NOS） and cyclic adenosine monophosphate （cAMP） in the pa- paverine group and Tet group was significantly higher than the ED group （P〈0. 05）. Conclusions If the corpus cavernosum penis was injected with tetrandrine, the penile corpus cavernosum smooth muscle can be effective relaxation and improve erectile function, which my increase the penis with the Camp content.

关 键 词：粉防己碱 勃起功能障碍 阴茎海绵体内压 CAMP 

分 类 号：R587.2[医药卫生—内分泌]