5-羟色胺受体基因多态性与海洛因依赖的关系  

ASSOCIATION BETWEEN THE POLYMORPHISM OF 5-HYDROXYTRYPTAMINE RECEPTOR GENE AND HEROIN DEPENDENCE

作　　者：赵俊红[1,2] 王智慧[2] 叶懿[1] 肖敏[1] 熊卉[1] 廖林川[1] 

机构地区：[1]四川大学华西基础医学与法医学院,成都610041 [2]四川大学华西药学院,成都610041

出　　处：《中国药物依赖性杂志》2013年第4期259-262,275,共5页Chinese Journal of Drug Dependence

基　　金：国家自然科学基金(30973369);教育部博士点基金项目(20090181110051)

摘　　要：目的獉獉:探讨5-HT1A受体基因(5-HTR1A)-1019C/G、5-HT1B受体基因(5-HTR1B)-681G/C、5-HT6受体基因(5-HTR6)-267C/T的多态性与海洛因依赖易感性的关系。方法獉獉:用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,检测70例海洛因依赖者(轻度依赖者、重度依赖者)和108例健康对照者的3个基因位点的基因型。结果獉獉:海洛因轻度依赖组和重度依赖组、依赖组和对照组之间3个位点的基因型和等位基因频率均无显著性差异。结论獉獉:没有证据表明5-HTR1A-1019C/G、5-HTR1B-681G/C和5-HTR6-267C/T的多态性与海洛因依赖易感性有关。Objective：To investigate the association between the polymorphism of 5 - HTR1A - 1019C/G,5 - HTR1B - 681 G/C, 5 - HTR6 - 267C/T and the susceptibility of heroin dependence. Met..h~_.ds...：The 3 SNPs of 70 heroin addicts（ heroin mild addicts and severe addicts）and 108 healthy controls were genotyped by polymerase chain reaction - restriction fragment length polymorphisms （ PCR -RFLP）. Results：No significant statistical differences in genotype and allele frequence of 5 -HTR1A - 1019C/G, 5 - HTR1B - 681G/C and 5 - HTR6 - 267C/T had been found between heroin mild dependence group, severe dependence group and control group. Conclusion：There was no evidence to show that 5 - HTR1A - 1019C/G,5 - HTR1B - 681G/C and 5 - HTR6 - 267C/T polymorphism may have association with the susceptibility of heroin dependence.

关 键 词：海洛因依赖 5-HT受体基因 多态性 

分 类 号：R681.02[医药卫生—骨科学]