凤丹籽饼粕单萜苷类成分的研究  

Monoterpene Glucosides in Seed Cakes of Paeonia ostii

作　　者：刘普[1] 李亮[1] 邓瑞雪[1] 卢宗元[1] 尹卫平[1] 

机构地区：[1]河南科技大学化工与制药学院,河南洛阳471023

出　　处：《中国药学杂志》2013年第17期1445-1448,共4页Chinese Pharmaceutical Journal

摘　　要：目的研究凤丹籽饼粕的化学成分。方法采用硅胶柱色谱、Toyopearl HW-40、Sephadex LH-20等多种柱色谱分离,制备高效液相色谱对有效部位进行分离、纯化,根据波谱数据分析鉴定化合物结构。结果从牡丹籽饼粕的正丁醇层分离得到7个单萜苷类化合物,分别鉴定为芍药苷(paeoniflorin,Ⅰ),氧化芍药苷(oxypaeoniflorin,Ⅱ),白芍苷(abiflofin,Ⅲ),4″-羟基白芍苷(4″-hydroxyl-albiflorinⅣ),牡丹酮-1-O-β-D-吡喃葡萄糖苷(1-O-β-D-glucopyransoyl-paeonisuffron,Ⅴ),β-gentiobiosyl-paeoniflorin(Ⅵ),白芍苷R1(abiflofin R1,Ⅶ)。结论所有化合物均为首次从凤丹种子及凤丹中分离得到的化合物。OBJECTIVE To study the chemical constituents of the seed cakes of Paeonia ostii. METHODS Chemical constitu- ents were isolated by Toyopearl HW - 40, Sephadex LH - 20, preparative HPLC, and silica gel column chromatographies. The structures were elucidated on the basis of spectral data analysis. RESULTS Seven monoterpene glucosides, paeoniflorin （ Ⅰ ）, oxypaeoniflorin （ Ⅱ）,abiflofin（Ⅲ）,4＂- hydroxylalbiflorin（Ⅳ）, 1-O-β-D-glucopyrzalsoylpaeonisuffron（ Ⅴ）,β-gentiobi-osylpaeoniflorin（Ⅵ）, and abi- flofin R1 （Ⅶ） were isolated from the seed cake of Paeonia ostii. CONCLUSION All the compounds are isolated from the seed cakes of Paeonia ostii for the first time.

关 键 词：凤丹 籽饼粕 化学成分 单萜苷类化合物 芍药苷 白芍苷 

分 类 号：R284[医药卫生—中药学]