孟鲁司特钠联合异丙托溴铵和布地奈德在儿童肺感染咳嗽中的应用  

Application of montelukast combined with ipratropium bromide and budesonide in treatment of cough in children with lung infection

作　　者：陆立东[1] 黄建萍[1] 华敏[1] 周雪梅[1] 

机构地区：[1]江苏省无锡市第三人民医院儿科,214041

出　　处：《中国妇幼保健》2013年第25期4172-4174,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨孟鲁司特钠联合异丙托溴铵和布地奈德治疗小儿支原体肺炎的临床疗效。方法:应用随机数字表法将112例支原体肺炎患者随机分为对照组56例和治疗组56例,对照组给予布地奈德和异丙妥溴胺;治疗组额外加用孟鲁司特钠4 mg/天,7天为1个疗程。用药结束后评价疗效,记录患者的症状体征消除时间和FEV1、PEF和FEV1/PVC等肺功能的变化情况。结果:治疗组总有效率为89.3%,显著高于对照组(P<0.05);两组患者治疗后FEV1、PEF和FEV1/PVC均明显升高(P<0.05);治疗组的体征(咳嗽、喘息、肺部啰音)消失时间均低于对照组,其中咳嗽消失时间显著低于对照组(P<0.05)。结论:孟鲁司特钠联合异丙托溴铵和布地奈德治疗小儿支原体肺炎疗效显著,可明显缩短患者临床体征消失时间,改善肺功能,值得在临床推广。Objective： To explore the clinical curative effect of montelukast combined with ipratropium bromide and budesonide in treatment of pediatric mycoplasma pneumonia. Methods： A total of 112 patients with mycoplasma pneumonia were randomly divided into control group and treatment group by random number table, 56 patients in each group; the patients in control group were treated with budes- onide and ipratropium bromide; the patients in treatment group were treated with montelukast （4 mg per day） combined with ipratropium bro- mide and budesonide, one course of treatment included seven days. The curative effects in the two groups were evaluated; the disappearance times of symptoms and signs and the changes of indexes of pulmonary function （FEV1, PEF and FEV1/PVC） were recorded. Results： The total effective rate in treatment group was 89. 3% , which was statistically significantly higher than that in control group （P 〈 0.05 ） ; in the two groups, FE^1, PEF and FEV1/P^C after treatment increased significantly （ P 〈 0. 05 ） ; the disappearance times of signs （ cough, wheeze, and pulmonary rales） in treatment group were shorter than those in control group, and there was statistically significant difference in the disappearance time of cough between the two groups （ P 〈 0.05 ） . Conclusion ： The curative effect of montelukast combined with iprat- ropium bromide and budesonide in treatment of pediatric mycoplasma pneumonia is significant, the method can obviously shorten the disap- pearance times of clinical signs and improve pulmonary function, which is worthy to be popularized in clinic.

关 键 词：肺炎 孟鲁司特钠 支原体 布地奈德 咳嗽 

分 类 号：R725.6[医药卫生—儿科]