黄芪甲苷对免疫低下糖尿病大鼠的影响  

The Effect of Astragaloside on Hypofunction of Immunity of Diabetes Rat

作　　者：刘必旺[1] 吉海杰[2] 许凯霞[1] 解冬[1] 朱冰清[1] 赵换[1] 

机构地区：[1]山西中医学院 [2]山西省中医院

出　　处：《山西中医》2013年第8期45-46,49,共3页Shanxi Journal of Traditional Chinese Medicine

基　　金：国家自然基金项目(81102553);国家"十二五"科技支撑项目(2011BAI07B01;2013BAI05B08);山西省科技攻关项目(20110313001-2);山西省特色重点学科中医学课题

摘　　要：目的:研究黄芪甲苷对免疫低下糖尿病大鼠的影响。方法:SD大鼠腹腔注射链脲佐菌素1次,环磷酰胺3次,造成免疫低下糖尿病模型动物,持续给药4周后,腹主动脉取血,分离血清,测定血糖、血常规、IgG、IL-2、INS水平,并进行胰腺组织形态学观察及胰岛素样生长因子(IGF)的检测。结果:免疫低下糖尿病动物模型造模成功,黄芪甲苷各剂量组的各项指标均有所改善。结论:黄芪甲苷可以使模型动物血糖降低,免疫力增强,是黄芪功效发挥的重要成分之一。Objective ： To study the effect of astragaloside on hypofunction of immunity loaded by diabetes rat. Methods： The animal models of diabetes with hypofunction of immunity were made by one time＇ s streptozotocin and 3 time＇ s cyclophosphamide intraperitoneal injection. Then they were divided into five groups which were model group, control group, and treatment group of high dose, medium dose and low dose. After 4 weeks＇ continue medication such index were determined as blood sugar, blood regular test, IgG, IL-2, and INS in the blood serum from abdominal aorta, pancreatic tissue histomorphology was observed, and insulin-like growth factor （IGF） was detected. Results： The correlated index in control group and treatment groups of each dosage were improved more than in model group. Conclusion： Astragaloside can cut down the animal models＇blood sugar and strengthen their immunity. Astragaloside is one of the active components in Radix astragali＇s efficacy of bringing into full play.

关 键 词：黄芪甲苷 黄芪 糖尿病 免疫低下 实验研究 

分 类 号：R285.5[医药卫生—中药学]