光引发剂MMMP的新合成工艺研究  

Study on Synthesis and Process Optimization of Photoinitiator MMMP

作　　者：熊伟[1] 徐保明[1] 阮华屹[1] 周云[1] 陈坤[1] 

机构地区：[1]湖北工业大学化学与环境工程学院,湖北武汉430068

出　　处：《化学世界》2013年第8期493-496,共4页Chemical World

基　　金：湖北省教育厅科研项目(D20111402);湖北省教育厅科研项目(DZ0111402);科技部科技人员服务企业项目(2009GJD10016);湖北省教育厅产学研重大项目(CXY2009A010);湖北省自然基金重点项目(2010CDA020)

摘　　要：以甲基苯基硫醚为原料,经付克酰基化、胺取代两步反应制得2-甲基-1-(4-甲硫基苯基)-2-吗啉基-1-丙酮(光引发剂MMMP),中间体、产物结构经1 H NMR,MS表征。重点考察了催化剂用量、温度、时间对付克酰基化反应收率的影响,以及原料配比、催化剂用量、溶剂种类对胺取代反应收率的影响,两步反应总收率达到85.0%。新工艺操作简单,反应条件温和,成本低,原料利用率高,适合工业化生产。2-Methyl-4＂-（methylthio）-2-morpholinopropiophenone （MMMP） was synthesized from methyl phenyl sulfide by Friedel-Crafts acylation and amine substitution. The structure of the intermediate and product was identified by 1H NMR spectroscopy and mass spectroscopy. The effect of the amount of cata- lyst, temperature and time on the yield of Friedel-Crafts acylation was investigated. To optimize amine substitution reaction conditions, experimental variables including ratio of raw materials, amount of cata- lyst and different kinds of solvents were studied. The total yield was 85.0%. The new method has the ad- vantages of convenient operation, mild reaction conditions, low cost and high utilization of raw material. It is suitable for industrial process.

关 键 词：光引发剂MMMP 甲基苯基硫醚 合成 

分 类 号：TQ243.4[化学工程—有机化工]