3-羟基氧化吲哚的不对称合成：金属催化和有机催化  

Metal Catalysis versus Organocatalysis in the Catalytic Asymmetric Synthesis of 3-Hydroxyoxindole

作　　者：刘运林[1] 朱锋[1] 王翠红[1] 周剑[1] 

机构地区：[1]华东师范大学化学系绿色化学与化工过程绿色化上海市重点实验室,上海200062

出　　处：《有机化学》2013年第8期1595-1615,共21页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.20902025,21172075);国家重点基础研究发展计划(973计划,No.2011CB808600);教育部新世纪优秀人才计划(No.NCET-11-0147);教育部博士新人奖(No.MXRZZ2012007)资助项目~~

摘　　要：3-取代的3-羟基氧化吲哚广泛存在于天然产物和药物活性分子中,是一类受到合成化学家广泛关注的优势骨架.近年来,围绕这一骨架的不对称催化合成取得了很大的进展.本综述旨在介绍几类重要的3-羟基氧化吲哚结构单元的不对称催化合成方法,藉此讨论有机催化和金属催化这两种不同催化模式各自的一些特点和优势之处.3-Substituted 3-hydroxyoxindoles are widely encountered in a large number of natural products, drugs and pharmaceutically active compounds. The catalytic asymmetric construction of this privileged skeleton has attracted great attention from synthetic chemistry, and much progress has been made in recent years. This review summarizes the advances in the catalytic enantioselective synthesis of four important types of subunits of 3-substituted 3-hydroxyoxindoles, and focuses on the discussion of the differences and advantages of metal catalysis and organocatalysis.

关 键 词：3-取代的3 羟基氧化吲哚 不对称催化 金属催化 有机催化 

分 类 号：O643.32[理学—物理化学]