钯催化的脂肪醇的芳基化反应研究进展  

Recent Developments on Pd-Catalyzed Arylations of Aliphatic Alcohols

作　　者：杨建平[1] 张莉[2] 金小平[3] 高浩其[1] 房江华[1] 李瑞丰[2] 方烨汶[1,4] 

机构地区：[1]宁波工程学院化学工程学院,宁波315016 [2]太原理工大学化学化工学院,太原030024 [3]浙江医药高等专科学校基础部,宁波315100 [4]宁波现代精细化工有限公司,宁波315204

出　　处：《有机化学》2013年第8期1647-1654,共8页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21202090);宁波市科技创新团队(No.2011B82002);浙江省自然科学基金(No.LY12B02001);宁波市自然科学基金(Nos.2011A610123;2012A610123)资助项目~~

摘　　要：烷基芳基醚结构广泛存在于天然和人工药物中,Pd催化的脂肪醇的芳基化反应是合成这类化合物的重要方法之一.重点综述了成功运用于脂肪醇的C—O偶联反应的四大类配体,对C—O偶联反应的应用进行了概述,对该类反应研究前景也进行了展望.Aromatic ethers of aliphatic alcohols represent an important structural motif in many naturally occurring and medicinally relevant compounds. Palladium-catalyzed aliphatic alcohol arylation is a kind of important methods to access them. This review focuses on four types of phosphorus ligands successfully employed in C--O cross coupling reactions of aliphatic alcohols. The applications of C--O cross coupling reactions are summarized and the reaction potential research areas are also discussed.

关 键 词：钯催化 烷基芳基醚 C-O偶联反应 膦配体 

分 类 号：O643.32[理学—物理化学]