丹地消银丸对银屑病样动物模型的影响  

Effect of Dandixiaoyin pill on psoriasis-like animal model

作　　者：刘冬平[1] 李蜀平[1] 刘魁英[1] 廖磊[1] 刘洋[1] 战嘉怡[1] 

机构地区：[1]北京市卫生局临床药学研究所科研项目部,北京100035

出　　处：《北京中医药》2013年第8期625-626,635,共3页Beijing Journal of Traditional Chinese Medicine

摘　　要：目的研究丹地消银丸对银屑病样动物模型的影响,为临床应用提供实验依据。方法以己烯雌酚造成小鼠阴道上皮有丝分裂模型,观察丹地消银丸对小鼠阴道上皮细胞有丝分裂的影响;建立鼠尾鳞片表皮模型,观察丹地消银丸促进小鼠尾部鳞片颗粒层形成的能力。结果丹地消银丸高、中剂量组可显著抑制雌激素期小鼠阴道上皮有丝分裂(P<0.05,P<0.01);高剂量组可显著提高小鼠尾部鳞片颗粒层形成数(P<0.01)。结论丹地消银丸对银屑病有良好的治疗作用,其作用机制与抑制表皮细胞的过度增生和改善表皮角化不全有关。Objective To study the effect of Dandixiaoyin pill （DDXY） on psoriasis-like animal model in order to provide experimental basis for clinical application. Methods The model of vaginal epithelium mitosis of mouse was established by diethylstilbestrol to observe the effect of DDXY on mitosis in vaginal epithelium cells of mouse; meanwhile, the mouse tail scale epidermis model was established to investigate the ability of DDXY in promoting the formation of stratum granulosum in mouse tail scale. Results The high and medium-dose DDXY groups could significantly inhibit vaginal epithelium mitosis of mouse in estrogen phase （P 〈 0.05, P 〈 0.01）; the high-dose DDXY group could significantly promote the formation of stratum granulosum in mouse tail scale （P 〈 0.01）. Conclusions DDXY has a good effect on psoriasis, and its mechanism is related with inhibiting hyperplasia and improving the parakeratosis of epidermal cells.

关 键 词：丹地消银丸 银屑病 动物模型 小鼠 

分 类 号：R285.5[医药卫生—中药学]