老年非透析2型糖尿病患者慢性肾脏病与外周动脉病变的关系  

Relationship between peripheral arterial disease and chronic kidney disease in elderly nondialysis patients with type 2 diabetes

作　　者：张萌[1] 邹海[2] 黄清梅[1] 万红梅[1] 杨金奎[3] 

机构地区：[1]南昌大学附属新余市人民医院内分泌科,江西省新余市338000 [2]温州医学院,325000 [3]北京同仁医院内分泌科,100000

出　　处：《实用医学杂志》2013年第17期2820-2822,共3页The Journal of Practical Medicine

摘　　要：目的：探讨老年非透析2型糖尿病患者中慢性肾脏病（CKD）与外周动脉病变（PAD）的关系。方法：500例老年2型糖尿病患者（平均年龄69岁，男性46．8％），以踝臂指数（ABI）≤0．9定为PAD，肾小球滤过率（GFR）估算值〈60mL／（min·1．73m。）定为CKD。应用多因素Logistic回归分析判断危险因素。结果：与非CKD患者相比，这些老年CKD患者中合并PAD的比例更高（42．6％vs 17.3％，P〈0．01）。调整传统危险因素后。CKD（OR=2．355，95％CI1．060～5．230）仍是ABI≤0．9的独立危险因素（P〈0．05）。结论：在老年非透析2型糖尿病患者中．GFR〈60mL／（min·1．73m2）与PAD发生独立相关，对这一高危人群进行PAD的早期诊断及治疗具有重大意义。Objective To explore the relationship between peripheral arterial disease （PAD） and chronic kidney disease （CKD） in elderly nondialysis patients with type 2 diabetes. Methods 500 elderly nondialysis patients with type 2 diabetes （mean age： 69 years, male： 46.8%） were included in this study. The ankle-brachial index （ABI） of ≤ 0.9 was diagnosed as PAD and an estimated GFR value of 〈 60 mL/（min- 1.73 m2） was diagnosed as CKD. Logistic multivariate regression analysis was used to determine the risk factors. Results The rate of PAD in patients with CKD was significantly higher than those without CKD （42.6% vs. 17.3%, P 〈 0.01 ）. CKD was still the independent risk factor for those with an ABI of ≤ 0.9 （OR = 2.355, 95%CI 1.060 - 5.230, P 〈 0.05）. Conclusions In elderly nondialysis patients with diabetes, GFR〈 60 mL/（min. 1.73 m2） is independently associated with the development of peripheral arterial disease. It is of important significance in the early diagnosis and treatment of peripheral arterial disease in these high-risk patients.

关 键 词：糖尿病 2型 慢性肾脏病 外周动脉病变 危险因素 

分 类 号：R692[医药卫生—泌尿科学]