V_5 dipic-Cl改善高脂诱导的肥胖C57BL/6J小鼠脂代谢紊乱的研究  

Effect of vanadium (Ⅴ)-chlorodipicolinate on lipid metabolism in high fat diet-induced C57BL/6J diabetic mice

作　　者：张伟 陈德亮[1] 张芳[1] 刘杨[1] 丁文军[1] 

机构地区：[1]中国科学院大学生命科学学院,北京100049

出　　处：《中国科学院大学学报（中英文）》2013年第5期613-619,共7页Journal of University of Chinese Academy of Sciences

基　　金：国家自然科学基金(11075207)资助

摘　　要：主要探讨有机钒化合物V5dipic-Cl对高脂饲料诱导的Ⅱ-型糖尿病C57BL/6J小鼠脂代谢的影响.结果表明,与糖尿病组相比,在给予V5dipic-Cl(5 mg/(kg·d))28 d后,小鼠的体重、血糖和白色脂肪组织显著降低;同时,V5dipic-Cl处理明显上调糖尿病小鼠肝中与脂肪酸氧化相关CPT1、ACO和FATP基因的mRNA表达水平.以上结果表明,V5dipic-Cl可以通过调控脂肪酸氧化相关基因的表达,改善糖尿病小鼠的脂代谢紊乱.The insulin-mimic effect of vanadium compounds has been reported in both type Ⅰ and Ⅱ diabetic animal models,but the effect of vanadium compounds on lipid metabolism remains to be fully understood.We investigate the effect of V5dipic-Cl on lipid metabolism in high fat diet-induced C57BL/6J diabetic mice.V5dipic-Cl was administered daily to the mice for 28 days at dose of 5 mg/（kg·d） by oral gavages.It was found that the blood glucose level and serum TG were significantly reduced after treatment with V5dipic-Cl.It is suggested that V5dipic-Cl improves the lipid metabolism by promoting fatty acid oxidation in liver.

关 键 词：V5dipic-Cl Ⅱ-型糖尿病 脂代谢紊乱 C57BL 6J 脂肪酸氧化 

分 类 号：Q591.5[生物学—生物化学]