单唾液酸四己糖神经节苷脂联合前列地尔治疗糖尿病周围神经病变的疗效观察  

Clinical observation of monosialotetrahexosylganglioside combined with alprostadil in treating patients with diabetic peripheral neuropathy

作　　者：管慧[1] 廖艳莉[1] 蔡文静[1] 

机构地区：[1]四川省凉山州第二人民医院内二科,615000

出　　处：《疑难病杂志》2013年第9期679-681,共3页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的观察单唾液酸四己糖神经节苷脂联合前列地尔治疗糖尿病周围神经病变的临床疗效。方法糖尿病周围神经病变患者70例随机分为2组,每组35例。在常规应用口服降糖药或胰岛素治疗的基础上,治疗组采用单唾液酸四己糖神经节苷脂联合前列地尔治疗,对照组采用前列地尔进行治疗。治疗2周后,对2组患者的临床疗效进行分析。结果治疗组的总有效率88.6%高于对照组的62.9%(P<0.05)。对照组疗效指数为(32.3±1.4)%,试验组疗效指数为(55.7±1.2)%,治疗组疗效指数显著高于对照组(P<0.01)。2组在治疗过程中均未发生明显不良反应。2组患者接受治疗后,对照组除正中神经MNCV外,正中神经、尺神经、腓浅神经的SNCV和MNCV均有一定程度的改善(P<0.01,P<0.05),且治疗组正中神经、尺神经,腓浅神经SNCV及正中神经MNCV均优于对照组(P<0.05,P<0.01)。结论单唾液酸四己糖神经节苷脂联合前列地尔治疗糖尿病周围神经病变疗效优于单用前列地尔。Objective To observe clinical efficacy of monosialotetrahexosylganglioside combined with alprostadil in treatment of diabetic peripheral neuropathy.Methods 70 patients with diabetic peripheral neuropathy were randomly divided into two groups,35 cases of each group.In the routine group use of oral hypoglycemic agents or insulin therapy,in the treatment group using monosialotetrahexosylganglioside combined with alprostadil,yet the control group was given alprostadil treatment. After 2 weeks of treatment,the clinical efficacy of the two groups was analyzed.Results The total effective rate of the treatment group was 88.6%,comparing with the control group（62.9%）,the difference was statistically significant（P 0.05）.The therapeutic effect index in treatment group was higher than control group（55.7%±1.2%vs 32.3%±1.4%）, there was significant difference（P 0.01）.Limb pain,numbness improvement rates of clinical improvement in the treatment group were respectively 87%and 90%,significantly higher than 71%and 72%of the control group.Fatigue,cold,sweating, diarrhea,dysuria improvement is better than the control group.Both of two groups didnt have significantly adverse reactions during treatment.Two groups of patients were treated,in addition to the median nerve MNCV in the control group,the median nerve,ulnar nerve,peroneal nerve SNCV and MNCV have a certain degree of improvement（P 0.01,P 0.05）, and the treatment group median nerve,ulnar nerve,peroneal nerve and median nerve MNCN SNCV than the control group （P 0.05,P 0.01）.Conclusion Monosialotetrahexosylganglioside combined with alprostadil treatment of diabetic peripheral neuropathy was better than alprostadil only.

关 键 词：糖尿病周围神经病变 单唾液酸四己糖神经节苷脂 前列地尔 

分 类 号：R587.2[医药卫生—内分泌]