三种苯甲酸琥珀酰亚胺酯的合成  

Synthesis of Three Kinds of Benzoic Acid Succinimidyl Ester

作　　者：范於菟[1] 武祥龙[1] 潘亚磊[1] 翟远坤[1] 梅其炳[1] 

机构地区：[1]西北工业大学生命学院空间生物实验模拟技术国防重点学科实验室,陕西西安710072

出　　处：《化学与生物工程》2013年第8期23-24,共2页Chemistry & Bioengineering

基　　金：国家自然科学基金资助项目(21202130);科技部973计划前期研究专项资助项目(2010CB535002)

摘　　要：以对甲氧基苯甲酸、3,4-二甲氧基苯甲酸、3,4,5-三甲氧基苯甲酸为原料,以三氟乙酸N-琥珀酰亚胺酯为活化剂合成了3种苯甲酸琥珀酰亚胺酯,经1 HNMR、IR对其结构进行了表征,并对反应投料比及反应时间进行了优化。Three kinds of benzoic acid succinimidyl ester were synthesized from three kinds of substituted benzoic acid with N-succinimidyl-trifluoroacetate as catalyst. Their structures were confirmed by 1HNMR, IR. Meanwhile,the reactant ratio and reaction time were optimized to increase the yield.

关 键 词：苯甲酸 苯甲酸琥珀酰亚胺酯 三氟乙酸N-琥珀酰亚胺酯 合成 

分 类 号：O625.631[理学—有机化学]