慢性牙周炎伴原发性高血压患者血清hs-CRP水平的检测及其意义  

Detection of serum levels of hypersensitivity C-reactive protein in patients with essential hypertension and periodontitis and clinical significance

作　　者：刘彦[1] 王雷[1] 林崇韬[1] 任春霞[1] 丁子清[1] 唐宇昕[1] 于海蛟[1] 

机构地区：[1]吉林大学口腔医院牙周病科,吉林长春130021

出　　处：《吉林大学学报（医学版）》2013年第4期795-798,共4页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅自然科学基金资助课题(201115105);吉林大学交叉学科基本科研业务经费资助课题(450060445270);吉林省长春市科技局社会发展科技计划项目资助课题(12SF82)

摘　　要：目的:检测慢性牙周炎并发高血压患者、单纯慢性牙周炎患者和健康对照者的牙周状况和血清中超敏C反应蛋白(hs-CRP)水平,探讨中、重度慢性牙周炎与原发性高血压之间的关系。方法:选取慢性牙周炎并发原发性高血压患者(慢性牙周炎并发高血压组)32例,中、重度慢性牙周炎患者(慢性牙周炎组)38例,健康志愿者(对照组)34例。记录受试者血压、全口牙齿牙周临床指标,包括菌斑指数(PLI)、探诊深度(PD)、附着丧失(AL)和出血指数(BI)。检测受试者血清中hs-CRP的含量。结果:慢性牙周炎并发高血压组患者PD、AL和BI显著高于慢性牙周炎组和对照组(P<0.05)。慢性牙周炎并发高血压组患者血清hs-CRP水平显著高于其他2组(P<0.05),且慢性牙周炎组患者血清hs-CRP水平也显著高于健康对照组(P<0.05),hs-CRP水平与PLI、PD、AL和BI呈显著正相关关系,相关系数(r)分别为0.400、0.521、0.668和0.540(P<0.05)。结论:高血压可以加重慢性牙周炎患者的牙周破坏程度,慢性牙周炎可以导致高血压患者血清hs-CRP水平升高。Objective To detect the periodontal status and the serum levels of hypersensitivity C reactive protein（hs-CRP）in the patients with chronic periodontitis and essential hypertension,the patients with single chronic periodontitis and healthy subjects,and to explore relationship between chronic periodontitis and essential hypertension.Methods There were 32patients with chronic periodontitis and essential hypertension,38patients with chronic periodontitis and 34healthy controls.The clinical periodontal parameters including plaque index（PLI）,probing depth（PD）,attachment loss（AL）and bleeding index（BI）were examined,and the serum levels of hs-CRP were tested.Results Compared with healthy group and chronic periodontitis group,the PD,AL and BI in chronic periodontitis and essential hypertension group were significantly increased（P0.05）.The hs-CRP level of the patients in chronic periodontitis and essential hypertension group was significantly higher than those in chronic periodontitis group and healthy group（P0.05）,and the hs-CRP level of the patients in chronic periodontitis group was significantly higher than that in healthy group（P0.05）.Conclusion Hypertension might increase the severity of chronic periodontitis,and chronic periodontitis may increase the level of serum hs-CRP in patients with hypertension.

关 键 词：牙周炎 原发性高血压 C反应蛋白 

分 类 号：R544.1[医药卫生—心血管疾病] R781.4[医药卫生—内科学]