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机构地区:[1]南京海陵中药制药工艺技术研究有限公司,南京210049
出 处:《中国实验方剂学杂志》2013年第17期8-11,共4页Chinese Journal of Experimental Traditional Medical Formulae
基 金:南京市2010年第二批科技发展计划项目(201002018)
摘 要:目的:优选南五味子总木脂素软胶囊的制备工艺。方法:采用紫外分光光度法测定总木脂素含量。选择玉米油和聚乙二醇600(PEG600)为分散剂,氢化植物油和羧甲基纤维素钠(CMC-Na)为稳定剂,聚山梨酯80(Tween80)为助溶剂,筛选内容物最佳处方。以胶囊收率和轧囊现象为综合评价指标,通过正交试验考察进料口温度、胶囊出口温度和转篮干燥时间对制备工艺的影响。结果:内容物最佳处方为主药-玉米油-PEG600-1,2-丙二醇-CMC-Na-氢化植物油-Tween80-水(44∶10∶15∶1∶8∶9∶3∶10),最佳制备工艺为进料口温度50℃,胶囊出口温度20℃,转篮干燥时间24 h。结论:优选的制备工艺稳定可行。Objective:To optimize preparation technology of total lignans from Schisandrae Sphenantherae Fructus softcapsules.Method:The content of total lignans was determined by UV spectrophotometry.With corn oil and polyethylene glycol 600(PEG600) as dispersant,hydrogenated vegetable oil and sodium carboxymethyl cellulose(CMC-Na) as stabilizer,polysorbate80(Tween80) as co-solvent,optimum prescription of capsules content was screened.With capsules yield and rolling phenomenon as comprehensive evaluation index,orthogonal test was adopted to investigate effects of inlet temperature,outlet temperature and rotating basket drying time on preparation technology.Result:The best prescription of capsules content was main medicine-corn oil-PEG600-1,2-propanediol-CMC-Na-hydrogenated vegetable oil-Tween80-water(44:10:15:1:8:9:3:10).Optimum preparation process was as following:dried by basket method at room temperature for 24 h with inlet temperature of 50 ℃ and outlet temperature at 20 ℃.Conclusion:This optimized process was feasible,stable and reasonable.
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