鸡眼睛正丁醇部位化学成分  

Chemical Constituents of Butanol Fraction of Euscaphis japonica

作　　者：周雯[1] 刘智[2] 王海军[1] 廖尚高[1] 许祖超 李勇军[1] 

机构地区：[1]贵阳医学院药学院,贵阳550004 [2]贵阳医学院附属医院药剂科,贵阳550004 [3]贵州益康制药有限公司,贵阳550025

出　　处：《中国实验方剂学杂志》2013年第17期93-96,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技支撑计划项目(2006BAI06A01-03);贵州省中药现代化科技产业研究开发专项项目(黔科合中药字[2011]5081号;黔科合中药专字[2007]5014号);贵州省科技计划课题(黔科合计工字[2009]4001);贵阳市科学技术计划项目(2009筑科中合同字第9-3-04号)

摘　　要：目的:了解鸡眼睛Euscaphis japonica正丁醇萃取部位的化学成分。方法:采用MCI柱色谱、C18反相硅胶柱色谱、半制备高效液相色谱等进行化合物的分离和纯化,根据化合物理化性质和波谱数据鉴定其结构。结果:从鸡眼睛乙醇提取物正丁醇部位分离得到7个化合物,分别鉴定为corchoionoside C(1)、鞣花酸(2)、junipetrioloside A(3)、3,3'-二甲氧基鞣花酸-4'-O-β-D-葡萄糖苷(4)、3,3'-二甲氧基鞣花酸-4'-O-α-D-阿拉伯糖苷(5)、3,3'-二甲氧基鞣花酸-4'-O-β-D-木糖苷(6)和3,3'-二甲氧基鞣花酸(7)。结论:以上化合物均为首次从该属植物中分离得到。Objective：To learn the chemical constituents of the butanol fraction of Euscaphis japonica.Method：Various column chromatographies（CCs） including MCI CC,RP-18 CC and semipreparative HPLC were employed for the isolation and purification of the constituents and their structures were determined by spectral analysis and chemical evidence.Result：Seven compounds were isolated and identified as corchoionoside C（1）,ellagic acid（2）,junipetrioloside A（3）,3,3’-di-O-methylellagic acid-4’-O-β-D-glucopyranoside（4）,3,3’-diO-methylellagic acid-4’-O-α-D-arabinfuranoside（5）,3,3’-di-O-methylellagic acid-4’-O-β-D-xylopyraoside（6） and 3,3’-di-O-methylellagic acid（7）.Conclusion：All compounds were isolated from E.japonica for the first time.

关 键 词：鸡眼睛 corchoionoside C 鞣花酸 junipetrioloside A 3 3’-二甲氧基鞣花酸 

分 类 号：R284.1[医药卫生—中药学]